倍他洛克对心脏自主神经系统的影响  

Effects of Betoloc on Autonomic Nervous System in the Heart

作　　者：谢正祥[1] 牛永红[1] 殷跃辉[2] 陈丽[3] 李章勇[1] 徐晓红[1] 

机构地区：[1]重庆医科大学生物医学工程研究室,重庆市400016 [2]重庆医科大学第二临床学院,重庆市400010 [3]川北医学院附属医院,南充市637000

出　　处：《中国药房》2002年第9期522-523,共2页China Pharmacy

基　　金：卫生部科学基金资助项目 (94-1-352)的后续项目

摘　　要：目的 :研究倍他洛克对心脏自主神经系统的影响。方法 :用我室研制的计算机分析系统 ,测定自愿受试者在给予倍他洛克(50mg,口服 )前和后3小时的心动周期信号的特征参数。结果 :倍他洛克能使心动周期、心动周期的标准差、谱的总功率、谱的高频成分显著增加 ,心率和谱的超低频成分的相对值 (Rpu)显著降低。结论 :(1)倍他洛克能使心动周期的标准差 (或心率的标准差 )增加 ,是使心动周期信号 (HPS)谱的高频成分显著增加的根本原因 ,也是副交感神经的张力增加的根本原因 ;(2)倍他洛克表现出降低心脏交感神经的张力 ,增加心脏副交感神经的张力 ,增加心脏自主神经系统的张力。OBJECTIVE:To study the effects of Betoloc(metoprolol)on autonomic nervous system in the heart METHODS:Using the computerized analysis system developed by our laboratory,the characteristic parameters of heart period signal(HPS)from volunteers were examined before and 3 hours after administrating Betoloc(50mg,po ) RESULTS:Betoloc could increase the mean heart period,standard deviation of heart period,high frequency components and total power of HPS'spectra,and decrease heart rate,low frequency components significantly CONCLUSION:(1)Betoloc can increase standard deviation of heart period or heart rate,which means increasing irregularity of heart rate It is the basic reason of increasing high frequency components of HPS'spectra and is also the basic reason of increasing cholinergic nervous activity;(2)Betoloc can decrease tension of sympathetic nerves,increase tension of parasympathetic nerves,and increase tension of autonomic nervous system in the heart

关 键 词：心动周期信号 谱特征 倍他洛克 心脏自主神经系统 

分 类 号：R969[医药卫生—药理学] R972[医药卫生—药学]