微生物法考察乳糖酸红霉素在不同输液中的稳定性  

Study on the Stability of Erythromycin Lactobionate in Different Kinds of Infusion Fluid by Microbioassay

作　　者：宁霞[1] 钟洁莲[1] 

机构地区：[1]广西壮族自治区妇幼保健院药剂科,南宁市530003

出　　处：《中国药房》2002年第9期554-556,共3页China Pharmacy

摘　　要：目的 :考察室温下6h内 ,注射用乳糖酸红霉素在5种输液中的稳定性。方法 :采用微生物检定法。结果 :室温下6h内 ,乳糖酸红霉素在5种输液中效价均有不同程度的降低 ,其中在葡萄糖或葡萄糖氯化钠输液中效价降低最快。结论 :乳糖酸红霉素与氯化钠注射液配伍优于与葡萄糖或葡萄糖氯化钠注射液配伍。OBJECTIVE:To study the stability of erythromycin lactobionate mixed with five kinds of infusion fluid at room temperature for 6 hours METHODS:Using microbioassay according to Chinese Pharmacopoeia(2000) RESULTS:The potency of erythromycin lactobionate in five kinds of fluid decreased to varying degrees when they were cultured at room temperature for 6 hours And the potency decreased most quickly when erythromycin lactobionate was mixed with glucose injection or glucose in NS CONCLUSION:Erythromycin lactobionate mixed with sodium chloride injection is more stable than that mixed with glucose injection or glucose in NS

关 键 词：微生物法 乳糖酸红霉素 输液 稳定性 

分 类 号：R927.11[医药卫生—药学] R978.15