阻塞性黄疸时血清内毒素和肿瘤坏死因子的变化及相互关系  

Changes and relationship of endotoxin and TNF-α in the serums of obstructive jaundice

作　　者：季福[1] 孙建华[1] 张晞文[1] 施维锦[1] 

机构地区：[1]上海第二医科大学附属仁济医院外科,上海200001

出　　处：《肝胆胰外科杂志》2002年第3期161-162,共2页Journal of Hepatopancreatobiliary Surgery

摘　　要：目的 :观察阻塞性黄疸发生时血清内毒素和TNF α的变化及相互关系。方法 :将大鼠随机分成对照组和胆总管结扎组 ,分别在第 3天、第 7天和第 2 1天测定血清内毒素和TNF α。结果 :胆总管结扎组的血清内毒素和TNF α逐渐升高 (P >0 .0 5 ,P <0 .0 5以及P <0 .0 1) ,两者相关系数为 0 .6 349(P <0 .0 0 1)。结论 :阻塞性黄疸发生时血清内毒素和TNF α明显升高 。Objective:To observe the changes and relationship of endotoxin and TNF α in the serums of obstructive jaundice.Methods:The rats randomly divided into control group and CBDL group and then the endotoxin and TNF α in the serums were determined.Results:The endotoxin and TNF α in the serums gradually increased in the CBDL group(P>0.05,P<0.05,P<0.01). The correlation between endotoxin and TNF α was 0.6349(P<0.001).Conclusion:The endotoxin and TNF α in the serums significantly increased in obstructive jaundice and there was positive correlation between them.

关 键 词：阻塞性黄疸 血清 内毒素 肿瘤坏死因子 

分 类 号：R657.4[医药卫生—外科学]