同位素催化交换法制备[G-~3H]-河鲀毒素  

Preparation of [G-~3H]-tetrodotoxin With Catalytic Isotope Exchange Reaction

作　　者：武德柱[1] 高巍[1] 

机构地区：[1]中国原子能科学研究院同位素研究所,北京102413

出　　处：《同位素》2002年第3期161-163,共3页Journal of Isotopes

摘　　要：采用同位素催化交换法制备了[G-3H]-河鱼屯毒素,并比较了催化气-液同位素交换反应与催化液-液同位素交换反应各自的特点。用薄层色层法分离、纯化产品,所获得的[G-3H]-河鱼屯毒素具有较高的放射性比活度和放化纯度。Catalytic isotope exchange reaction is used to prepare tetrodotoxin,the specificity is also compared between catalytic gas liquid isotope exchange reaction and catalyic liquid liquid isotope exchange reaction. The thin layer chromatography is used to separate and puritfy the product. The obtained product have high radiochemical purity and specific activity.

关 键 词：同位素催化交换法 [G-^3H]-河Tun毒素 神经毒素 氚 神经系统药物 药物代谢 放射性示踪 

分 类 号：R971[医药卫生—药品] R969.1[医药卫生—药学]