反相高效液相色谱-二极管阵列检测同时测定去痛片中4组分的含量  

Simultaneous Determination of Four Components in Commercial Analgesic Tablets by Reversed Phase High Performance Liquid Chromatography-Diode Array Detector

作　　者：刘道杰[1] 王霞[1] 孙吉令 

机构地区：[1]聊城师范学院化学系,聊城252059 [2]山东省药品检验所,济南250012

出　　处：《分析化学》2002年第9期1106-1108,共3页Chinese Journal of Analytical Chemistry

摘　　要：建立了一种同时测定去痛片中 4组分的含量的反相高效液相色谱法。采用YWGC1 8柱 ,以甲醇 磷酸二氢钠 (35∶6 5 )为流动相 ,流速为 1.0mL min ,用二极管阵列检测器检测 ,检测波长为 2 14nm。该方法简便快捷 ,线性范围广 ,结果准确可靠 ,用于实际样品的测定 ,结果满意。A reversed phase high performance liquid chromatographic method was proposed for the simultaneous determination of the aminopyrine, phenobarbital, phenacetin and caffeine in analgesic tablets. In this method, a YWG C 18 column was used with methanol and sodium dihydrophosphate as mobile phase. The flow rate was 1.0 mL/min. The diode-array detector was used and the detection wavelength was 214 nm. The method is simple and fast with wide linear range. It has been applied to determine real samples with satisfactory results.

关 键 词：反相高效液相色谱 二极管阵列检测法 去痛片 氨基比林 非那西丁 苯巴比妥 咖啡因 解热镇痛药 药物含量测定 

分 类 号：O657.7[理学—分析化学]