微流控芯片与生物质谱联用技术的发展与展望  

The Development and Foreground of Microfluidic Device Coupled to Bio-Mass Spectrometry

作　　者：水雯箐[1] 苏佳[1] 黄珍玉[1] 黄懿[1] 杨芃原[1] 

机构地区：[1]复旦大学化学系,上海200433

出　　处：《质谱学报》2002年第2期100-111,99,共13页Journal of Chinese Mass Spectrometry Society

摘　　要：本文系统归纳了当前微流控电泳芯片与生物质谱的联用模式。芯片材质涵盖玻璃与高聚物 ,与接口衔接的电离手段包括电喷雾电离 ( ESI)和基质辅助激光解析电离 ( MAL DI)。Microfluidic devices have been coupled to mass spectrometers (MS) though their dimensions seem unlikely for marriage. Three types of interface designs are concluded for MS with electrospray ionization while some novel means is also reported to couple microchip to MALDI-TOF. The substrate of microfluidic devices cover both glass and plastic. Various integrated protein preparation and preconcentration procedures together with its trend toward multiplexing are also reviewed.

关 键 词：联用技术 发展 微流控芯片 生物质谱 电泳芯片 生物大分子 分析 

分 类 号：Q503[生物学—生物化学] O657.63[理学—分析化学]