肝毒清颗粒治疗慢性乙型肝炎内毒素血症的临床研究  

Clinical Study on the Treatment of Gan Du Qing Granule of 60 Patients of En-dotoxemia Complicated by Chronic Hepatitis B

作　　者：魏嵋[1] 杨华秀[1] 刘鹏 汪静 苑聚蓉 

机构地区：[1]泸州医学院附属中医院,646000

出　　处：《中西医结合肝病杂志》2002年第4期199-201,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：四川省教育厅重点科研项目(No:01 LA34)

摘　　要：目的:观察肝毒清颗粒治疗慢性乙型肝炎并发内毒素血症的临床疗效。方法:将116例慢性乙型肝炎内毒素血症患者随机分成两组。其中60例以肝毒清颗粒配合西药治疗作为治疗组,56例以乙肝宁冲剂配合西药治疗作为对照组。观察治疗后的总有效率,及肝功能、内毒素和TNF-α、IL-6的变化。结果:治疗组总有效率(83.3％)优于对照组(53.6％,P<0.05),且在清除血浆内毒素,改善肝功能,降低TNF-α、IL-6方面,与对照组比较,均有显著差异(P<0.05或P<0.01)。结论:肝毒清颗粒治疗慢性乙型肝炎并发内毒素血症疗效显著,其主要机制与降低血浆内毒素水平及血清TNF-α,IL-6水平有关。Objective: To observe the clinical effect of Gan Du Qing Granule. Method: 116 patients of endotoxemia complicated by chronic hepatitis B were divided into 2 groups randomly. The therapeutic group of 60 patients was treated with western medicine plus Gan Du Qing, the control group of 56 patients was treated with western medicine plus Yi Gan Ning Granule preparation. The total efficiency rate, the indexes of liver function and the changes of endotoxin and level of TNF-α, IL-6 were observed in both groups after the treatment. Results: The total efficiency rate of the test group (83.3% ) was higher than that of the control group (53.6% , P<0.05). There was a significant difference between the test group and control group as to the improvement of liver function and the decrease of the endotoxin and TNF-α, IL-6 (P<0.05 or P<0.01). Conclusion: The curative effect of Gan Du Qing Granule was obvious on endotoxemia of active hepatitis B. The decrease of endotoxin and TNF-α, IL-6 may be one of the main mechanisms.

关 键 词：慢性乙型肝炎 肝毒消颗粒 内毒素血症 肝瘤坏死因子-α 白细胞介素-6 疗效 

分 类 号：R259[医药卫生—中西医结合]