检测尿Ⅰ型胶原交联氨基末端肽监测抗骨吸收药物疗效的特异性评价  

Evaluation the specificity of urine-NTx in monitoring the effectiveness of antiresorptive therapy

作　　者：程志强[1] 尹潍[2] 樊继援[2] 马同军 

机构地区：[1]天津医科大学总医院内分泌科,北京协和医院内分泌科300075 [2]天津医科大学总医院内分泌科注,北京300075

出　　处：《临床内科杂志》2002年第5期359-361,共3页Journal of Clinical Internal Medicine

基　　金："九五"国家科技攻关资助项目( 96 90 6 0 5 0 6 )

摘　　要：目的　研究检测尿I型胶原交联氨基末端肽 (NTx)监测抗骨吸收药物疗效的作用。方法　将 46名绝经后妇女随机分成治疗组 (阿仑磷酸钠 10mg/d ,6个月 )和对照组 (安慰剂 ,6个月 )。用ELISA法检测尿NTx值 ,双能X线骨密度仪测定腰椎骨密度。结果　治疗组和对照组的NTx和骨密度的改变率分别为 -5 1.64 %、5 %和 5 .16%、-2 .5 8%,治疗组的骨吸收指标均下降 ,以NTx下降最明显 ,近 5 1.4%(P <0 .0 0 1) ,对照组的NTx值却有所上升。Objective To investigate the effect of urine NTx in monitoring the effects of treatment osteoporosis with anti resorption drugs.Methods 46 subjects were randomly divided into two groups, treated with oral Alendronate 10mg per day (28 cases) or placebo (18 cases), respectively, for 6 months.BMD of lumbar spine and urine NTx were analysed at the beginning and the end of the study.Results The change rate of BMD and urine NTx in the treatment and control group were 51.64%,5% and 16%,-2.58%;Markers of bone resorption were decreased after Alendronate therapy,urine NTx was signicificantly decreased to 51.4%( P <0.001), and there were increased in placebo group.Conclusions NTx would be used suitably to monitor the effects of antiresorptive treatment of osteoporosis.

关 键 词：绝经 骨矿盐密度 骨质疏松症 尿I型胶原交联氨基末端肽 

分 类 号：R969[医药卫生—药理学]