2型糖尿病患者可溶性细胞间粘附分子-1、E-选择素水平的变化  

Changes of sICAM-1 and sE-selectin in typy 2 diabetic patients

作　　者：温玉洁[1] 姜友珍[2] 秦艳玲[2] 

机构地区：[1]广西壮族自治区第二人民医院内分泌科,桂林541002 [2]广西壮族自治区第二人民医院检验科,桂林541002

出　　处：《临床内科杂志》2002年第5期366-368,共3页Journal of Clinical Internal Medicine

基　　金：广西区科技厅 2 0 0 0年广西科学研究与技术开发计划项目资助 (桂科攻 0 0 150 4 7)

摘　　要：目的　研究 2型糖尿病患者血清可溶性细胞间粘附分子 1(sICAM 1)和可溶性E 选择素 (sE selectin)水平的变化。方法　应用酶联免疫吸附法测定 67例 2型糖尿病患者和 2 0例健康对照组的sICAM 1和sE selectin以及甘油三酯 (TG)水平。结果　 ( 1) 2型糖尿病组血清sICAM 1和sE selectin水平显著高于对照组 (P <0 .0 1) ,2型糖尿病有微血管病变组、有大血管病变组均高于无血管病变组 (P值均 <0 .0 5 ) ;( 2 ) 2型糖尿病患者血清sICAM 1和sE selectin之间呈正相关关系 (r =0 .9985 ,P <0 .0 1) ;( 3 )血清sICAM 1水平和TG之间呈正相关关系 (r =0 .415 ,P <0 .0 5 )。结论　血清sICAM 1和sE selectin参与了糖尿病大血管和微血管病变的发病过程 ,并可作为糖尿病病情变化的监测指标 ,2型糖尿病患者血清sICAMObejective To investigate the change of serum levels of sICAM 1 and of sE selectin in type 2 diabetic patients.Methods Serum levels of sICAM 1 and sE selectin were measured with ELISA in 67 cases of type 2 dibetic patients and 20 cases of healthy subjects.Results ①The serum levels of sICAM 1 and sE selectin in type 2 diabetic patients were much higher than these in healthy controls respectively ( P < 0.01), serum levels of sICAM 1 and sE selectin in type 2 diabetic patients with microangiopathy and large vessel diseases were much higher than those in type 2 diabetic patients without vessel diseases( P < 0.05); ②Serum levels of sICAM 1 in type 2 diabetic patients had positive correlative with serum levels of sE selectin( r =0.9985, P <0.01);③Serum levels of sICAM 1 in type 2 diabetic patients had positive correlative with serum levels of hypertriglyceridemia( r =0.415. P <0.05).Conclusions Serum sICAM 1 and sE selectin might participate in the course of diabetic microangiopathy and large vessel disease.Serum levels of sICAM 1 and sE selectin are the useful markers in reflecting disease evolution in diabetes mellitus.The elevation of serum levels of sICAM 1 in type 2 diabetic patients is related to hypertriglyceridemia.

关 键 词：2型糖尿病 可溶性细胞间粘附分子-1 E-选择素 

分 类 号：R587.1[医药卫生—内分泌]