小单孢菌FIM98-160产生的抗分枝杆菌抗生素labilomycin  

Labilomycin, an antimycobacterium antibiotic produced by Micromonospora sp.FIM98-160

作　　者：连云阳[1] 谢阳[1] 魏天恩[1] 郑卫[1] 程元荣[1] 

机构地区：[1]福建省微生物研究所国家新药(微生物)筛选实验室,福州350007

出　　处：《中国抗生素杂志》2002年第9期516-520,共5页Chinese Journal of Antibiotics

基　　金：福建省自然科学基金项目项目编号C9810 0 4 7

摘　　要：在筛选抗结核杆菌药物的过程中 ,从福州水库底土样品中分离到小单孢菌FIM98 1 60 ,对该菌株作分类鉴定 ,抗菌物质的分离纯化 ,所得化合物含有三个组分 ,其中A组分经理化性质、光谱特征和生物学活性研究 ,证明它与链霉菌产生的labilomycin同质。它是首次从小单孢菌代谢产物中分离得到。During the course of screening for novel anti tuberculosis antibiotics, a strain FIM98 160 was isolated from soil sample collected in Fuzhou China. Based on the taxonomic study, it was identified as Micromonospora sp. Three components, A, B and C, were found in the bioactive compound of its culture broth. The component A, Fw98 160A, was isolated and purified. The results of the studies on its physico chemical properties and spectra and its biological activities showed that Fw98 160A was identical with labilomycin, which has been isolated from culture of Streptomyces strains. This is the first report that labilomycin was isolated from the culture of Micromonospora sp.

关 键 词：FIM98-160 小单孢菌 Labilomycin Pulvomycin 抗结核抗生素 多药耐药 结核杆菌 生物活性 

分 类 号：R978.3[医药卫生—药品]