白背叶根对肝纤维化大鼠的实验研究  

Experimental Study on the Root of Mallotus Apelta(Lour.)Muell.-Arg. in Rats with Liver Fibrosis

作　　者：赵进军[1] 吕志平[1] 张绪富[1] 

机构地区：[1]第一军医大学中医系,广东广州510515

出　　处：《现代诊断与治疗》2002年第5期257-259,共3页Modern Diagnosis and Treatment

基　　金：全军医药卫生科研基金课题资助项目

摘　　要：目的　通过大鼠肝纤维化动物模型 ,研究白背叶根防治肝纤维化的作用 ,并探讨其作用机理。方法　采用 40 %CCl4花生油溶液制备大鼠肝纤维化模型 ,观察白背叶根对大鼠血清中多项指标及组织病理学改变的影响。观察的血清学指标包括 :白蛋白 (ALB)、球蛋白 (GLB)、丙氨酸转氨酶 (ALT)、天门氨酸转氨酶 (AST)、透明质酸 (HA )、层粘蛋白(LN)、前三型胶原 (PⅢC)和四型胶原 (CollagenⅣ )。 结果　白背叶根能显著降低大鼠血清中GLB、ALT、HA、LN和Col lagenⅣ的水平 ,并能减轻肝脏内炎症和胶原纤维增生程度。 结论　白背叶根具有较好的抗肝纤维化作用。Objective To investigate the effect of the root of Mallotus apelta(Lour.)Muell. Arg. in the prevention and the treatment of liver fibrosis through the rat model,and to discuss its mechanism.Method Liver fibrosis rat model was prepared with 40% CCl 4 in peanut oil.A series of items in the blood were detected,including ALB,GLB,ALT,AST,HA,LN,PⅢC and Collagen Ⅳ.The changes of the liver tissue were observed too.Results The serum levels of GLB,ALT,HA,LN and Collagen Ⅳ decreased significantly,while the degrees of liver inflammation and collagen fibers proliferation were successfully relieved after the treatment.Conclusion The root of Mallotus apelta(Lour.)Muell. Arg. could retard the progression of liver fibrosis.

关 键 词：白背叶根 肝纤维化 中药治疗 药理学 

分 类 号：R259.752[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]