多形核粒细胞在急性胰腺炎肝损害中的作用  

Effect of Polymorphonuclear Neutrophils on Liver Damage in Acute Pancreatitis

作　　者：石力[1] 田伏洲[1] 黄大熔[1] 王雨[1] 李晓军[1] 尹志良[1] 

机构地区：[1]成都军区总医院全军普外中心,成都610083

出　　处：《中国普外基础与临床杂志》2002年第5期332-334,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　观察急性胰腺炎发生时 ,肝脏中多形核粒细胞 (polymorphonuclearneutrophil ,PMN )浸润与肝损害间的关系。方法　Wistar大鼠 72只 ,随机分为急性胰腺炎组、急性胰腺炎PMN消耗组及对照组。分别于术后 3h、6h、12h及 2 4h观察血浆丙氨酸氨基转移酶 (ALT)、肝组织髓过氧化物酶 (MPO)及肝组织病理改变。结果　在急性胰腺炎诱导 6h后 ,肝组织中MPO明显增加并呈进行性增高。同时 ,肝脏的病理改变及肝功能损害也呈进行性加重。消耗循环PMN后 ,肝组织中MPO水平明显下降 ,肝脏的病理改变及肝功能损害也同时得以减轻。结论　肝组织中PMN浸润在急性胰腺炎肝损害过程中具有重要的作用。Objective To evaluate the effect of polymorphonuclear neutrophils (PMN) on liver damage in acute pancreatitis. [WT5”HZ]Methods [WT5”BZ]Seventy-two wistar rats were randomly divided into acute pancreatitis (AP) group, acute pancreatitis with PMN depleted (APD) group and sham operation (SO) group. Liver damage was assessed by histological changes and the level of alanine aminotransferase (ALT) in serum. The number of PMN infiltration in liver was reflected by myeloperoxidase (MPO). [WT5”HZ]Results [WT5”BZ]MPO significantly increased from 6 to 24 hours in AP and APD groups. However, the level of MPO was significantly higher in AP group than that in APD group. ALT significantly increased from 3 to 24 hours in these two groups, but the level of ALT was significantly lower in APD group than that in AP group. Meanwhile, the hepatic pathological changes were more severe in AP group than that in APD group. [WT5”HZ]Conclusion [WT5”BZ]PMN play an important role in liver damage during acute pancreatitis. [WT5”HZ]

关 键 词：急性胰腺炎 多形核粒细胞 肝损害 发病机制 

分 类 号：R657.510.2[医药卫生—外科学]