丹参、三七不同比例配伍对正常家兔血小板聚集性、粘附性的影响  

Effect of Dan-shen,San-qi of Different Proportion on Platelet Aggregation and Adhesion in Normal Rabbits

作　　者：刘婷[1] 秦彩玲[1] 张毅[1] 康立源[2] 孙有富[1] 张伯礼[2] 

机构地区：[1]中国中医研究院中药研究所,北京100700 [2]天津中医药大学,天津300193

出　　处：《中国中药杂志》2002年第8期609-611,共3页China Journal of Chinese Materia Medica

基　　金：国家重点基础研究发展规划项目 (19990 5 44 0 3 )

摘　　要：目的 :观察了丹参、三七 6种不同比例配伍对正常家兔血小板聚集性、粘附性的影响。方法 :新西兰兔 ,灌胃给药 4d ,颈总动脉放血 ,比浊法测定血小板聚集率 ,粘附实验采用旋转玻球法。结果与结论 :阿司匹林 4 .4mg·kg-1能明显抑制正常家兔血浆血小板聚集性和全血血小板粘附性 ;丹参∶三七 10∶0 ,10∶1,10∶3,10∶6 ,1∶10及 0∶10 6种比例配伍 ,对正常家兔血浆血小板聚集性均有明显的抑制作用 ,其中以 10∶3为最佳 ,而 0∶10即单味三七对正常家兔血浆血小板聚集性无明显影响 ;丹参∶三七 10∶3、10∶6及 0∶10 3种比例配伍 ,对正常家兔血小板粘附性均有明显的抑制作用 ,而其最佳配伍为 :0∶10 ,丹参∶三七 10∶0 ,10∶1及 1∶10 3种比例配伍对正常家兔血小板粘附性无明显影响。Objective:To observe the effect of the crude extracts of Dan shen root and San qi of different proportion on platelet aggregation and adhesion in normal rabbits. Method:With rabbits, ig.(4d, exsanguinated via carotid artery, percentage of platelet aggregation and adhesion was measured. Result and Conclusion: Aspirin (4.4mg/Kg) could markedly inhibit platelet aggregation and adhesion in normal rabbit. The proportions of Dan shen root /San qi (10∶0, 10∶1, 10∶3, 10∶6, 1∶10) could markedly inhibit platelet aggregation, among which 10∶3 was the best. San qi alone had little effect on aggregation. The proportions of Dan shen root/ San qi (10∶3, 10∶6 , 0∶10) could markedly inhibit platelet adhesion, among which 0∶10 was the best,and the proportions(10∶0,10∶1 ,1∶10) had little effect.

关 键 词：丹参 三七 中药配伍 血小板聚集 血小板粘附 

分 类 号：R285.5[医药卫生—中药学]