慢性肝炎对氯氮平血药浓度的影响  

The Effect of Chronic Hepatitis on Serum Concentration of Clozapine

作　　者：卢卫红[1] 章连生[1] 朱丽萍[1] 金通观[1] 杜亚松[1] 

机构地区：[1]上海市精神卫生中心,201108

出　　处：《中原精神医学学刊》2000年第2期71-73,共3页

摘　　要：为探讨不同类型不同严重程度慢性肝炎对氯氮平及去甲氯氮平血浓度的影响,对92例合并慢性肝炎(分慢性迁延型肝炎、慢性活动型肝炎两型及轻度、中度、重度三种严重程度)和40例无肝脏疾病的精神分裂症病人,于服药后2周、6周末检测氯氮平血药浓度。结果显示,中度、重度慢性肝炎及慢性活动性肝炎与对照组均有显著差异,轻度慢性肝炎及慢性迁延型肝炎与对照组比较均无显著差异,而慢性肝炎各型及各严重程度与对照组去甲氯氮平浓度均无显著差异。In order to study the serum concentration of clozapine affected by differ-end type and variable severity of chronic hepatitis. 92 cases of schizophrenia with chronic hepatitis (devided into chronic persistent hepatitis, chronic active hepatitis as well as mild, middle and severe groups) and 40 schizophrenic patients without any hep-atitic disease were tested for serum concentration of clozapine after 2 and 6 weeks of taking clozapine. The results showed that the serum concentration of clozapine on middle, severe chronic hepatitis and CAH are significantly different from that in controls, where the mild chronic hepatitis and CPH have no difference from that in controls. The concentration of norclozapine in all groups of chronic hepatitis has little difference from that in controls.

关 键 词：慢性肝炎 氯氮平 血药浓度 影响 精神分裂症 

分 类 号：R971.4[医药卫生—药品] R969.1[医药卫生—药学]