青蒿素及其衍生物免疫抑制作用的实验研究  

Experimental Study on the Immunosuppressive Effects of Qinghaosu()and Its Derivative

作　　者：孙秀珍[1] 谢蜀生[2] 龙振洲[2] 张文仁[2] 屠呦呦[3] 

机构地区：[1]长春职工医科大学,130051 [2]北京医科大学免疫学教研室,北京100083 [3]中国中医研究院中药研究所

出　　处：《中西医结合杂志》1991年第1期37-38,共2页

基　　金：卫生部重点课题资助项目

摘　　要：本实验研究了青蒿素(QHS)及青蒿素衍生物(DQHS)的免疫调节作用,结果表明,经腹腔注射25～100mg/kg 剂量的 QHS 及 DQHS 都能明显地抑制小鼠抗体分泌细胞(PFC)数。在100mg/kg 剂量下,QHS 及 DQHS 能明显抑制牛血清白蛋白(BSA)诱导的小鼠迟发型超敏反应(DTH);抑制小鼠脾细胞对 ConA 及 LPS 的增殖反应;抑制小鼠脾细胞产生白细胞介素-2(IL-2)这些结果表明,青蒿素及其衍生物对小鼠体液免疫和细胞免疫均有明显的抑制作用。In this report the researchers studied the immunosuppressive effects of Qinghaosu(QHS)and its derivative(DQHS).The results indicated that after 7-day successive administration i.p of QHS and DQHS at the dosage of 25～100 mg/kg,the amounts of anti-SRBC IgM PFC and IgG PFC in the murine spleen were decreased significantly(P<0.01).At the dosage of 100 mg/kg the QHS and DQHS were able to inhibit the DTH induced with BSA and the proliferative responses of murine apleen cells to Con A and LPS.These results suggested the suppressive effects of QHS and DQHS on both humoral and cellular immunities of mice.Interleukin-2(IL-2)is an inportant mediate in the immune response and plays a critical role in the activation and differentiation of T and B lymphocytes.The results in this report showed a significant suppression of IL-2 production of mourine spleen cells after 7-day administration i.p of QHS and DQHS,which suggested that the inhibition of IL-2 production could be the important one of the mechanisms of the immunosuppressive effects of QHS and DQHS.

关 键 词：青蒿素 免疫抑制 白细胞介素 

分 类 号：R978.61[医药卫生—药品]