赤芍注射液治疗慢性肺心病、肺动脉高压的临床研究  

Clinical Study on Paeonia lactiflora Injection in Treating Chronic Cor Pulmonal with Pulmonary Hypertension

作　　者：贾雁宾 汤泰秦[2] 

机构地区：[1]武汉市第四医院,研究生武汉430033 [2]湖北中医学院附属医院

出　　处：《中西医结合杂志》1991年第4期199-202,共4页

摘　　要：本研究用心肺阻抗血流图、血液粘度检查,动脉血气分析以及右心导管术等方法比较观察了42例肺心病患者静脉、肺动脉注射100%赤芍液的临床疗效。结果显示:赤芍注射液能扩张肺血管、降低肺动脉压力和肺血管阻力,增加心输出量,改善右心功能和血液流变性,提高氧分压,使临床瘀血体征显著改善,是防治肺心病、肺动脉高压较为适用的中药制剂。The changes of clinical features of blood stasis,hemorheology,arterial blood gas and hemodynamics which was determined by impedance cardiogram and pheopneumogram,hemor- heologic examination,blood gaseous analysis and right heart catheterization were observed in 42 patients(male 35,female 7;age 64±16.5 years),32 patients with decompensative chronic cor pulmonal(CCP).served as noninvasive methods group(NMG)treated by intravenous injecting 100% Paeonia lactifiora injection 5 ml per day,10 patients with CCP as well aspulmonary hypertension, which was proved through right heart catheterization were considered as invasive methods group (IMG)treated by pulmonary artery injecting 100% Paeonia lactiflora 5 ml(one time).After the treatment,the clinical features of blood stasis were improved significantly in NMG(P<0.05).Also the results of impedance cardiogram and pheopneumogram(such as:Q-B,B-Yinterval and Q-B/B-Y ratio,cardiac output),the hemorheologic parameters(such as:blood viscosity,plasma viscosity, hematoerit and erythrocyte electrophoresis)and oxygen consumption of myocardium were im- provecd significantly in NMG and IMG.In IMG,PAP was reduced by 0.71±0.27 kPa;PaO_2 was promoted significantly in NMG.All of these have statistical significance(P<0.05 or 0.01).There are no statistical significance about the change of PaCO_2,SaO_2,blood pH and Bp(P<0.05).

关 键 词：赤芍注射液 肺动脉高压 瘀血症 

分 类 号：R541.505[医药卫生—心血管疾病]