血清Ⅳ-C、TNF和IL-6检测对慢乙肝与肝硬化的临床价值  

The Clinical Value of Serum Ⅳ-C,TNF and IL-6 Detection for Chronic Hepatitis B and Cirrhosis

作　　者：黄维丽[1] 苏玉林[1] 朱高红[1] 

机构地区：[1]昆明医学院第一附属医院核医学科,云南昆明650031

出　　处：《标记免疫分析与临床》2002年第3期133-134,共2页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨血清Ⅳ -C、TNF和IL - 6检测对慢乙肝与肝硬化的临床价值。应用RIA测定 4 4例慢乙肝、31例肝硬化患者和 32名正常人血清Ⅳ -C、TNF和IL - 6。 4 4例慢乙肝和 31例肝硬化患者血清Ⅳ -C、TNF、IL - 6含量均明显增高 ,与正常组相比有显著性差异 (P <0 .0 1) ,肝硬化患者血清TNF含量明显高于慢乙肝患者 ,慢乙肝患者血清IL - 6含量明显高于肝硬化患者 ,两者之间有显著性差异 (P <0 .0 1)。对慢乙肝与肝硬化患者分别测定Ⅳ -C、TNF和IL - 6 ,能从不同的侧面反映其肝细胞炎症。To investigate the clinical value of serum Ⅳ-C,TNF and IL-6 detection for chronic hepatitis B and cirrhosis, 44 patients with chronic hepatitis B, 31 patients with cirrhosis and 32 normal controls have been detected by RIA. The contents of serum Ⅳ-C, TNF and IL-6 on 44 patients with chronic hepatitis B and 31 patients cirrhosis all increased evidently. Compared with normal persons group, there exists a significance level of difference ( P <0.01). Serum TNF content of cirrhosis group is evidently higher than chronic hepatitis B group; serum IL-6 content of chronic hepatitis B group is evidently higher than the cirrhosis group. Between both groups there is a notable difference( P <0.01).Separately performing Ⅳ-C, TNF and IL-6 detection for patients with chronic hepatitis B and cirrhosis will reflect the hepatocyte inflammation, necrosis and hepatic fibrillation extent through different flanks.

关 键 词：Ⅳ-C TNF IL-6 慢乙肝 肝硬化 

分 类 号：R512.6[医药卫生—内科学]