老年矽肺结核患者转化生长因子-α水平的临床研究  

Clinical Research of Serum Transforming Growth Factor-α in Old Patients with Silicotuberculosis

作　　者：叶一秀[1] 王巍[1] 姜平[2] 刘伟民[1] 陈东进[2] 李洪敏[1] 冯柏[2] 姚昊[1] 张韬[1] 欧阳晓辉[1] 

机构地区：[1]解放军第309医院核医学科,结核科,北京100091 [2]北京市矿务局医院,北京102300

出　　处：《标记免疫分析与临床》2002年第3期138-139,共2页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨老年矽肺结核患者血清转化生长因子 -α(TGF -α)水平的变化 ,采用放射免疫法检测了 6 9例老年矽肺结核患者的血清TGF -α水平 ,并与老年肺结核患者和健康老年人做了比较。结果表明 ,老年矽肺结核患者的TGF -α水平显著高于健康老年人和老年肺结核患者 (P <0 .0 1) ,老年肺结核患者和老年健康人血清TGF-α水平相差无显著性 (P >0 .0 5 )。TGF -α水平与痰菌无明显相关。为此 ,老年矽肺结核患者血清TGF -α水平显著增高 。To study the change of transforming growth factor-α(TGF-α) in old patients with silicotuberculosis, the serum TGF-α in 69 patients with silicotuberculosis were measured by RIA, and compared with that in the group of old patients with pulmonary tuberculosis and the old normal control. The level of serum TGF-α in old patients with silicotuberculosis was singnificantly higher than that in the others( P < 0.01), and there was no singnificant difference between pulmonary tuberculosis and old normal control( P >0.05). The level of TGF-α does not correlate with numbers of bacterium in sputum. The level of serum TGF-α in old patients with silicotuberculosis was higher than that of pulmonary tuberculosis and old normal control. The change regularity of TGF-α should been studied further.

关 键 词：肺结核 矽肺 转化生长因子-Α 

分 类 号：R521[医药卫生—内科学]