2型糖尿病患者干预治疗后血浆内皮素含量变化及其临床意义  

The Changes in Plasma Endothelin after Dosing Intervention in Type 2 Diabetes and Its Clinical Significance

作　　者：杨希秀[1] 孙金风[1] 李鲁生[1] 王淑芳[1] 赵鑫[1] 

机构地区：[1]济南市中心医院,山东济南250013

出　　处：《标记免疫分析与临床》2002年第3期140-141,共2页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨糖尿病微血管并发症与胰岛素抵抗、血浆内皮素 (ET)水平的相关性。对 82例 2型糖尿病患者接受药物干预治疗前后及 30名正常人采用放射免疫分析法测定血浆ET并进行糖耐量、胰岛素 -C肽释放试验 ,结果显示 :糖尿病患者治疗后各指标均明显下降 ,IAI与血浆ET呈负相关 ,在伴有微血管病变中变化更明显 (P<0 .0 1)。提示胰岛素敏感性和内皮系统完整性在某些方面是关联的 ,药物干预治疗在减弱胰岛素抵抗及延缓2型糖尿病血管并发症的发生。To explore the correlation of endothelin(ET), insulin resistance and microvascular complications in type 2 diabetes, the serum concentrations of OGTT, INS, C-P and plasma ET were measured by radioimmunoassay in 30 normal subjects and 82 patients with type 2 biabetes. ET level had a linear negative correlationship with IAI. The level of ET were significantly greater in group with microangiopathy than in group without microangiopathy( P <0.01). Insulin sensitivity are strongly correlated with vascular endothelial cells. The intervention may play an important role in decreasing insulin resistance of type 2 diabetes, and it is a vascular complications.

关 键 词：2型糖尿病 干预 治疗 胰岛素抵抗 内皮素 

分 类 号：R587.1[医药卫生—内分泌]