严重急性呼吸综合征(SARS)中的神经肌肉障碍  

Neuromuscular disorders in severe acute respiratory syndrome

作　　者：Tsai L.K. Hsieh S.T. Chao C.C. Y.C.Chang 郭俊 

机构地区：[1]Department of Neurology, National Taiwan University Hospital , No. 7 Chung Shan South Rd, Taipei 100, Taiwan Dr.

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第3期18-19,共2页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Objective: To delineate and clarify neuromuscular disorders in patients with p robable severe acute respiratory syndrome (SARS). Design: Case series with follo w up ranging from 3 weeks to 2 months. Setting: National Taiwan University Hosp ital, Taipei. Patients: We investigated 4 patients with SARS who had concomitant neuromuscular problems. A diagnosis of SARS was based on the demonstration of s erum coronavirus antibodies. Clinical presentations, laboratory results, electro physiologic findings, and follow up conditions were determined. Results: Patien ts developed neuromuscular problems approximately 3 weeks after the onset of SAR S. Two women experienced motor predominant peripheral nerve disorders. A man de veloped myopathy and a third woman experienced neuropathy and myopathy. Cerebros pinal fluid obtained from 2 patients with neuropathy disclosed normal protein co ntent and the absence of pleocytosis and SARS coronavirus antibodies. Both patie nts with myopathy had elevated serum creatine kinase levels. A rapid clinical an d electrophysiologic improvement was evident during follow up examinations, wit h a good prognosis. Conclusions: The neuromuscular problems in patients with SAR S are considered to be critical illness polyneuropathy or myopathy, possibly co existent. Further pathological and microbiological studies are necessary to dete rmine the relationship between SARS coronavirus and neuromuscular problems.Objective: To delineate and clarify neuromuscular disorders in patients with p robable severe acute respiratory syndrome (SARS). Design: Case series with follo w up ranging from 3 weeks to 2 months. Setting: National Taiwan University Hosp ital, Taipei. Patients: We investigated 4 patients with SARS who had concomitant neuromuscular problems. A diagnosis of SARS was based on the demonstration of s erum coronavirus antibodies. Clinical presentations, laboratory results, electro physiologic findings, and follow up conditions were determined. Results: Patien ts developed neuromuscular problems approximately 3 weeks after the onset of SAR S. Two women experienced motor predominant peripheral nerve disorders. A man de veloped myopathy and a third woman experienced neuropathy and myopathy. Cerebros pinal fluid obtained from 2 patients with neuropathy disclosed normal protein co ntent and the absence of pleocytosis and SARS coronavirus antibodies. Both patie nts with myopathy had elevated serum creatine kinase levels. A rapid clinical an d electrophysiologic improvement was evident during follow up examinations, wit h a good prognosis. Conclusions: The neuromuscular problems in patients with SAR S are considered to be critical illness polyneuropathy or myopathy, possibly co existent. Further pathological and microbiological studies are necessary to dete rmine the relationship between SARS coronavirus and neuromuscular problems.

关 键 词：神经肌肉 抗冠状病毒抗体 肌病 电生理检查 疑似患者 脑脊液检查 微生物学研究 台湾大学 血清肌酸激酶 诊断标准 

分 类 号：R511.9[医药卫生—内科学]