三维对比增强磁共振血流成像对主动脉上血管狭窄闭塞性疾病的无创检测:一项与数字减影血管造影进行个体间比较的前瞻性研究  

Noninvasive detection of steno-occlusive disease of the supra-aortic arteries with three-dimensional contrast-enhanced magnetic resonance angiography: A prospective, intra-individual comparative analysis with digital subtraction angiography

作　　者：Willinek W.A. Von Falkenhausen M. Born M. 雷翀 

机构地区：[1]Department of Radiology, University of Bonn, Sigmund- Freud- Strasse 25, D- 53105 Bonn, Germany Dr.

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第6期50-50,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Background and Purpose - Concomitant disease of the supraaortic arteries can influence the outcome of surgical treatment of carotid artery stenosis. However, sensitivity and specificity data of noninvasive contrast- enhanced 3- dimensional (3D) magnetic resonance angiography (CE MRA) for the detection of stenoocclusive disease of the entire supra- aortic arteries including the circle of Willis remain unclear. We aimed to intra- individually compare high- spatial- resolution CE 3D MRA and digital subtraction angiography (DSA) for the assessment of steno- occlusive vascular disease of the supra- aortic arteries. Methods - CE MRA and DSA of the supra- aortic arteries were prospectively performed in 50 consecutive patients. Intra- individual comparison of CE MRA and DSA was available in 833 arteries. High- spatial- resolution CE MRA comprised a measured voxel size of 0.81 mm × 0.81 mm × 1 mm (0.66 mm3). Steno- occlusive vascular disease of the 833 arteries was assessed independently by 2 radiologists according to the NASCET criteria. Results - CE MRA had a sensitivity of 100% (73/73), a specificity of 99.3% (760/765), a positive predictive value of 93.6% (73/78), and a negative predictive value of 100% (760/760) by using a 70% to 99% threshold of arterial diameter stenosis. For detection of occlusion, sensitivity, specificity, PPV, and NPV value of CE MRA were 100% , respectively. Conclusions - Noninvasive high- spatial- resolution CE MRA is suited to replace diagnostic DSA for the detection of stenoocclusive disease of the supra- aortic arteries.Background and Purpose - Concomitant disease of the supraaortic arteries can influence the outcome of surgical treatment of carotid artery stenosis. However, sensitivity and specificity data of noninvasive contrast- enhanced 3- dimensional (3D) magnetic resonance angiography (CE MRA) for the detection of stenoocclusive disease of the entire supra- aortic arteries including the circle of Willis remain unclear. We aimed to intra- individually compare high- spatial- resolution CE 3D MRA and digital subtraction angiography (DSA) for the assessment of steno- occlusive vascular disease of the supra- aortic arteries. Methods - CE MRA and DSA of the supra- aortic arteries were prospectively performed in 50 consecutive patients. Intra- individual comparison of CE MRA and DSA was available in 833 arteries. High- spatial- resolution CE MRA comprised a measured voxel size of 0.81 mm × 0.81 mm × 1 mm (0.66 mm3). Steno- occlusive vascular disease of the 833 arteries was assessed independently by 2 radiologists according to the NASCET criteria. Results - CE MRA had a sensitivity of 100% (73/73), a specificity of 99.3% (760/765), a positive predictive value of 93.6% (73/78), and a negative predictive value of 100% (760/760) by using a 70% to 99% threshold of arterial diameter stenosis. For detection of occlusion, sensitivity, specificity, PPV, and NPV value of CE MRA were 100% , respectively. Conclusions - Noninvasive high- spatial- resolution CE MRA is suited to replace diagnostic DSA for the detection of stenoocclusive disease of the supra- aortic arteries.

关 键 词：闭塞性 磁共振血流成像 无创检测 大脑动脉环 高空间分辨率 特异度 阴性预测值 动脉直径 阳性预测值 

分 类 号：R543.3[医药卫生—心血管疾病]