帕金森病患者的单侧苍白球切开术与双侧丘脑下核团刺激对神经心理功能影响的对比研究  

Unilateral pallidotomy versus bilateral subthalamic nucleus stimulation in PD: A comparison of neuropsychological effects

作　　者：Smeding H.M.M. Esselink R.A.J. Schmand B. 赵正卿 

机构地区：[1]Dept. of Neurology,H2-222, Academic Medical Center, P. O. Box 22660, 1100 DD Amsterdam,Nethe rlands

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第8期43-43,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Objective: To compare the cognitive and behavioural effects of unilateral pall idotomy and bilateral subthalamic nucleus (STN)stimulation. Methods: After basel ine examination 34 patients were randomly assigned to unilateral pallidotomy (4 left-sided,10 right-sided) or bilateral STN stimulation (n=20). At baseline an d six and twelve months after surgery we administered neuropsychological tests o f language, memory, visuospatial function, mental speed and executive functions. Also a depression rating scale, and self and proxy ratings of memory and dysexe cutive symptoms were administered. Results: Six months after surgery, the STN gr oup and the pallidotomy group differed significantly in change from baseline in number of errors on two tests of executive functioning. After 12 months the STN group reported less positive affect compared with baseline than the pallidotomy group. One patient in the STN group showed an overall cognitive deterioration du e to complications.Conclusions: Although we need larger groups to draw firm conc lusions, our results suggest that bilateral STN stimulation has slightly more ne gative effects on executive functioning than unilateral pallidotomy.Objective: To compare the cognitive and behavioural effects of unilateral pall idotomy and bilateral subthalamic nucleus (STN)stimulation. Methods: After basel ine examination 34 patients were randomly assigned to unilateral pallidotomy (4 left-sided,10 right-sided) or bilateral STN stimulation (n=20). At baseline an d six and twelve months after surgery we administered neuropsychological tests o f language, memory, visuospatial function, mental speed and executive functions. Also a depression rating scale, and self and proxy ratings of memory and dysexe cutive symptoms were administered. Results: Six months after surgery, the STN gr oup and the pallidotomy group differed significantly in change from baseline in number of errors on two tests of executive functioning. After 12 months the STN group reported less positive affect compared with baseline than the pallidotomy group. One patient in the STN group showed an overall cognitive deterioration du e to complications.Conclusions: Although we need larger groups to draw firm conc lusions, our results suggest that bilateral STN stimulation has slightly more ne gative effects on executive functioning than unilateral pallidotomy.

关 键 词：苍白球 帕金森病 神经心理 核团 刺激组 空间定向 试验结果 

分 类 号：R651[医药卫生—外科学] R395[医药卫生—临床医学]