西班牙人颈动脉扩张性的遗传度:北曼哈顿家族研究  

Heritability of carotid artery distensibility in hispanics: The Northern Manhattan Family Study

作　　者：Juo S.-H.H. Rundek T. 高宗恩 

机构地区：[1]Columbia University Genome Center, 1150 Saint Nicholas Ave, New York, NY 10032, United States

出　　处：《世界核心医学期刊文摘（神经病学分册）》2006年第3期47-48,共2页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Background and Purpose -Reduced arterial distensibility has been introduced as a novel risk factor for atherosclerosis. The importance of the genetic contribution to variation in distensibility is largely unknown. The purpose of this study was to estimate heritability of carotid distensibility. Methods -The ongoing Northern Manhattan Family Study recruits high-risk Caribbean Hispanic families to study genetic effects on stroke/cardiovascular risk factors. The distensibility metrics (strain, stiffness, distensibility, and elastic modulus) were measured from the right common carotid artery, and the heritability for each was estim ated. Variance component methods were used to estimate age-and sex-adjusted heritability. Correlations were calculated to evaluate the relationship between di stensibility phenotypes and intimamedia thickness (IMT) at each carotid segment. Results -The current data included 88 probands and 605 relatives from 88 famil ies. Age-and sex-adjusted heritability was 25%for strain, 17%for distensibil ity, 20%for stiffness, and 20%for elastic modulus. Without adjustment for cova riates, strong correlations were found between distensibility metrics and IMT: t he absolute values of correlation coefficients were between 0.2 and 0.5, and all P values were < 0.001. However, the correlation coefficients were reduced subst antially after adjusting for age and sex. Conclusions -These results suggested that genetic factors explained a moderate proportion of the variability of carot id distensibility. The correlations between distensibility and IMT were mainly a ttributable to age and sex effects. The regulation of carotid distensibility and IMT may reflect different underlying genetic and environmental mechanisms.Background and Purpose -Reduced arterial distensibility has been introduced as a novel risk factor for atherosclerosis. The importance of the genetic contribution to variation in distensibility is largely unknown. The purpose of this study was to estimate heritability of carotid distensibility. Methods -The ongoing Northern Manhattan Family Study recruits high-risk Caribbean Hispanic families to study genetic effects on stroke/cardiovascular risk factors. The distensibility metrics (strain, stiffness, distensibility, and elastic modulus) were measured from the right common carotid artery, and the heritability for each was estim ated. Variance component methods were used to estimate age-and sex-adjusted heritability. Correlations were calculated to evaluate the relationship between di stensibility phenotypes and intimamedia thickness (IMT) at each carotid segment. Results -The current data included 88 probands and 605 relatives from 88 famil ies. Age-and sex-adjusted heritability was 25%for strain, 17%for distensibil ity, 20%for stiffness, and 20%for elastic modulus. Without adjustment for cova riates, strong correlations were found between distensibility metrics and IMT: t he absolute values of correlation coefficients were between 0.2 and 0.5, and all P values were < 0.001. However, the correlation coefficients were reduced subst antially after adjusting for age and sex. Conclusions -These results suggested that genetic factors explained a moderate proportion of the variability of carot id distensibility. The correlations between distensibility and IMT were mainly a ttributable to age and sex effects. The regulation of carotid distensibility and IMT may reflect different underlying genetic and environmental mechanisms.

关 键 词：遗传度 家族研究 内膜中层厚度 动脉扩张 西班牙人 协变量 颈总动脉 血管危险因素 弹性系数 紧张度 

分 类 号：R543.5[医药卫生—心血管疾病]