应用重组卵泡刺激素和促性腺激素释放激素拮抗剂诱发排卵的体外受精患者,卵泡期延长可导致较低的继续妊娠率  

Prolongation of the follicular phase in in vitro fertilization results i n a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle -stimulating hormone and gonadotropin-releasing hormone antagonists

作　　者：Kolibianakis E.M. Albano C. Camus M. 闫坤 

机构地区：[1]Centre for Reproductive Medicine,Dutch-Speaking Brussels Free Univ., Brussels, Belgium Dr.

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第1期29-29,共1页Core Journal in Obstetrics/Gynecology

摘　　要：Objective To assess the effect of altering the timing of hCG administ ration on ongoing pregnancy rates in patients stimu-lated with recombinant FSH (rec-FSH ) and GnRH antagonists for IVF. Design Prospective, randomized, controlled trial . Setting Tertiary referral center. Patient(s) Four hundred thirteen patients un dergoing IVF. Intervention(s) Rec-FSH stimulation starting on day 2 of the cycl e combinedwith daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized to receive 10,000 IU of hCG either as soon as at least three fol licles were ≥17 mm on ultrasound (early-hCG group, 208 patients) or 2 days lat er after this criterion was met (late-hCG group, 205 patients). Main outcome me asure(s) Ongoing pregnancy rate. Result(s) Fertilization rates and number and qu ality of embryos transferred did not differ between the two groups. However, a s ignificantly lower ongoing pregnancy rate was present in the late-hCG as compar ed with the early-hCG group (25.0%vs. 35.6%, respectively). Conclusion(s) Pro longation of the follicular phase in patients stimulated with rec-FSH and GnRH antagonists for IVF does not affect oocyte or embryo quality but is associated w ith a significantly lower ongoing pregnancy rate.Objective To assess the effect of altering the timing of hCG administ ration on ongoing pregnancy rates in patients stimu-lated with recombinant FSH (rec-FSH ) and GnRH antagonists for IVF. Design Prospective, randomized, controlled trial . Setting Tertiary referral center. Patient(s) Four hundred thirteen patients un dergoing IVF. Intervention(s) Rec-FSH stimulation starting on day 2 of the cycl e combinedwith daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized to receive 10,000 IU of hCG either as soon as at least three fol licles were ≥17 mm on ultrasound (early-hCG group, 208 patients) or 2 days lat er after this criterion was met (late-hCG group, 205 patients). Main outcome me asure(s) Ongoing pregnancy rate. Result(s) Fertilization rates and number and qu ality of embryos transferred did not differ between the two groups. However, a s ignificantly lower ongoing pregnancy rate was present in the late-hCG as compar ed with the early-hCG group (25.0%vs. 35.6%, respectively). Conclusion(s) Pro longation of the follicular phase in patients stimulated with rec-FSH and GnRH antagonists for IVF does not affect oocyte or embryo quality but is associated w ith a significantly lower ongoing pregnancy rate.

关 键 词：体外受精 诱发排卵 卵泡刺激素 卵泡期 卵母细胞 拮抗剂 卵泡直径 月经周期 给药时间 受精率 

分 类 号：R714.8[医药卫生—妇产科学]