应用促性腺激素释放激素拮抗剂后血清黄体生成素浓度对体外受精-胚胎移植妊娠率无显著影响  

Luteinizing hormone concentrations after gonadotropin-releasing hormone antagonist administration do not influence pregnancy rates in in vitro fertiliz ation-embryotransfer

作　　者：Merviel P. Antoine J.-M. Mathieu E. 闫坤 

机构地区：[1]Department of Gyne cology, Obstetrics and Reproductive Medicine, Hˇopital Tenon, Paris, France Dr.

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第1期29-30,共2页Core Journal in Obstetrics/Gynecology

摘　　要：Objective To determine the impact of circulating LH concentrations du ring cont rolled ovarian hyperstimulation on the outcome of IVF. Design Retrospective stud y. Setting University hospital. Patient(s) Two-hundred seventy women who had a short stimulation protocol with GnRH antagonist and ovarian stimulation with rec ombinant FSH (rFSH). Intervention( s)GnRHantagonist and rFSH were administered S C; blood samples were collected on the day of GnRH antagonist administration, 1 day after, and on the day of hCG administration. Main outcome measure(s) A thres hold of 0.5 IU/L on the day of hCG was chosen to discriminate between women with LH concentrations ≤0.5 IU/L (group A, n = 119) or >0.5 IU/L (group B, n = 151) . Result(s) The two groups were comparable with regard to the clinical parameter s. In group A, significantly lower LH concentrations were observed on day 9 of t he cycle and on the day of hCG administration. The numbers of oocytes retrieved, embryos obtained, and embryos cryopreserved were significantly higher in group A compared with group B. The proportion of clinical pregnancieswas similar in th e two groups (21.1%vs. 22.7 %per ET). Conclusion(s) In GnRH antagonist and rFS H protocols, suppressed serum LH concentrations do not have any influence on the final stages of follicular maturation, pregnancy rates, or outcomes.Objective To determine the impact of circulating LH concentrations du ring cont rolled ovarian hyperstimulation on the outcome of IVF. Design Retrospective stud y. Setting University hospital. Patient(s) Two-hundred seventy women who had a short stimulation protocol with GnRH antagonist and ovarian stimulation with rec ombinant FSH (rFSH). Intervention( s)GnRHantagonist and rFSH were administered S C; blood samples were collected on the day of GnRH antagonist administration, 1 day after, and on the day of hCG administration. Main outcome measure(s) A thres hold of 0.5 IU/L on the day of hCG was chosen to discriminate between women with LH concentrations ≤0.5 IU/L (group A, n = 119) or >0.5 IU/L (group B, n = 151) . Result(s) The two groups were comparable with regard to the clinical parameter s. In group A, significantly lower LH concentrations were observed on day 9 of t he cycle and on the day of hCG administration. The numbers of oocytes retrieved, embryos obtained, and embryos cryopreserved were significantly higher in group A compared with group B. The proportion of clinical pregnancieswas similar in th e two groups (21.1%vs. 22.7 %per ET). Conclusion(s) In GnRH antagonist and rFS H protocols, suppressed serum LH concentrations do not have any influence on the final stages of follicular maturation, pregnancy rates, or outcomes.

关 键 词：黄体生成素 体外受精 诱发排卵 卵泡刺激素 卵泡成熟 卵母细胞 冷藏胚胎 拮抗剂 皮下给药 受孕率 

分 类 号：R714.8[医药卫生—妇产科学]