在分裂期和囊胚期胚胎移植的效果相同:一项前瞻性随机研究。  

Embryo transfer is equally effective at cleavagestage and blastocyst stage: A randomized prospective study

作　　者：Hreinsson J. Rosenlund B. Fridstrm M. 赵巍 

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第4期29-30,共2页Core Journal in Obstetrics/Gynecology

摘　　要：Objective: To compare the implantation and pregnancy rates after cleavage stage embryo transfer (ET) with transfer of blastocyststage (days 5-6) embryos. Study design: Prospective randomized trial at an assisted reproduction unit in a university hospital. Women with six or more follicles at the last ultrasound scan before oocyte aspiration were randomized for transfer of a maximum of two embryos after 2-3 days (n = 80) or after 5-6 days (n = 64) of culture. Embryo quality, implantation and pregnancy rates were evaluated. Statistical significance was tested with the Chisquare test and Fishers exact test. Result(s): No significant difference was observed in implantation rates (21.1%versus 20.9%, respectively) and clinical pregnancy rates (36.7%versus 32.5%respectively) after blastocyst and cleavage stage transfers for the two groups. The pregnancy rate among subjects who had at least one good quality embryo transferred was 37.5%per day 2-3 ET and 60%per day 5-6 ET. Conclusion(s): The overall implantation and pregnancy rates after embryo transfer at cleavage stage and at blastocyst stage transfer were not statistically different. Women who had at least one good quality blastocyst (n = 25) had a high pregnancy rate (60%per ET). Blastocyst transfer is a good alternative for couples with many good quality embryos on day 2 after insemination.Objective: To compare the implantation and pregnancy rates after cleavage stage embryo transfer (ET) with transfer of blastocyststage (days 5-6) embryos. Study design: Prospective randomized trial at an assisted reproduction unit in a university hospital. Women with six or more follicles at the last ultrasound scan before oocyte aspiration were randomized for transfer of a maximum of two embryos after 2-3 days (n = 80) or after 5-6 days (n = 64) of culture. Embryo quality, implantation and pregnancy rates were evaluated. Statistical significance was tested with the Chisquare test and Fishers exact test. Result(s): No significant difference was observed in implantation rates (21.1%versus 20.9%, respectively) and clinical pregnancy rates (36.7%versus 32.5%respectively) after blastocyst and cleavage stage transfers for the two groups. The pregnancy rate among subjects who had at least one good quality embryo transferred was 37.5%per day 2-3 ET and 60%per day 5-6 ET. Conclusion(s): The overall implantation and pregnancy rates after embryo transfer at cleavage stage and at blastocyst stage transfer were not statistically different. Women who had at least one good quality blastocyst (n = 25) had a high pregnancy rate (60%per ET). Blastocyst transfer is a good alternative for couples with many good quality embryos on day 2 after insemination.

关 键 词：胚胎移植 分裂期 囊胚期 着床率 随机研究 囊胚移植 受孕率 卵母细胞 精确检验法 附属医院 

分 类 号：R714.8[医药卫生—妇产科学]