习惯性自然流产史女性凝血异常和高凝突变的评估  

Evaluation of the prevalence of haemostatic abnormalities and hypercoagulation mutations in women with a history of recurrent spontaneous abortions (Germ)

作　　者：Bussen S. Mulfinger L. Frambach T. 王雅楠 

机构地区：[1]Universitts-Frauenklinik, Josef-Schneider-Straβe 4, 97080 Würzburg, Germany

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第4期53-53,共1页Core Journal in Obstetrics/Gynecology

摘　　要：Purpose: This study was undertaken to evaluate the incidence of haemostatic abnormalities and hypercoagulation mutations in women with a history of three or more consecutive spontaneous abortions and to investigate the influence of the antiphospholipid autoantibody status. Material and Methods: 20 nonpregnant habitual aborters were analysed for prothrombin time, activated partial thromboplastin time, fibrinogen, plasminogen, protein S, protein C, antithrombin III, and antiphospholipid autoantibodies. Genetic analysis was performed to detect factor V Leiden mutation and factor II G20210A mutation. Twenty healthy nonpregnant multigravidae served as controls. Results: The incidence of haemostatic abnormalities or of factor II or V Leiden mutations did not differ significantly between women with a history of recurrent spontaneous abortion and controls. In 9 of 20 women with recurrent spontaneous abortions antiphospholipid autoantibodies (APA) were detectable. APApositive and APAnegative study patients revealed similar results with respect to the investigated coagulation values Conclusion: According to our observations a general screening for hereditary coagulation disorders or hypercoagulation mutations should not be included in the routine workup of women with a history of recurrent spontaneous abortions unless there is a history of familiar thrombophilia.Purpose: This study was undertaken to evaluate the incidence of haemostatic abnormalities and hypercoagulation mutations in women with a history of three or more consecutive spontaneous abortions and to investigate the influence of the antiphospholipid autoantibody status. Material and Methods: 20 nonpregnant habitual aborters were analysed for prothrombin time, activated partial thromboplastin time, fibrinogen, plasminogen, protein S, protein C, antithrombin III, and antiphospholipid autoantibodies. Genetic analysis was performed to detect factor V Leiden mutation and factor II G20210A mutation. Twenty healthy nonpregnant multigravidae served as controls. Results: The incidence of haemostatic abnormalities or of factor II or V Leiden mutations did not differ significantly between women with a history of recurrent spontaneous abortion and controls. In 9 of 20 women with recurrent spontaneous abortions antiphospholipid autoantibodies (APA) were detectable. APApositive and APAnegative study patients revealed similar results with respect to the investigated coagulation values Conclusion: According to our observations a general screening for hereditary coagulation disorders or hypercoagulation mutations should not be included in the routine workup of women with a history of recurrent spontaneous abortions unless there is a history of familiar thrombophilia.

关 键 词：自然流产史 习惯性流产 凝血异常 抗磷脂自身抗体 血栓形成倾向 抗凝血酶Ⅲ 凝血因子 遗传分析 无显著性差异 经产 

分 类 号：R714.21[医药卫生—妇产科学]