洗涤后活动精子总数是宫腔内人工受精妊娠结局的预测因子:一项荟萃分析  

Performance of the postwash total motile sperm count as a predictor of pregnancy at the time of intrauterine insemination: A meta-analysis

作　　者：Van Weert J.-M Repping S Van Voorhis B.J 陈媛媛 

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第5期24-24,共1页Core Journal in Obstetrics/Gynecology

摘　　要：To assess the performance and clinical value of the postwash total motile sper m count (postwash TMC) as a test to predict intrauterine insemination (IUI) outc ome. Meta-analysis of diagnostic tests. Tertiary fertility center. Patients und ergoing IUI. We detected 16 studies that reported on postwash TMC at inseminatio n and IUI outcome. Summary receiver operating characteristics (ROC) curves indic ated a reasonable predictive performance toward IUI outcome, and, at cut-off le vels between 0.8 to 5 million motile spermatozoa, the postwash TMC provided a su bstantial discriminative performance. At these cut-off levels, the specificity of the postwash TMC, defined as the ability to predict failure to become pregnan t, was as high as 100%; the sensitivity of the test, defined as the ability to predict pregnancy, was limited. The postwash TMC at insemination could potential ly be used in counseling patients for either IUI or IVF. However, to enable pati ent counseling before the start of treatment, further studies are needed to esta blish the accuracy of a postwash TMC during the fertility workup rather than at insemination.To assess the performance and clinical value of the postwash total motile sper m count (postwash TMC) as a test to predict intrauterine insemination (IUI) outc ome. Meta-analysis of diagnostic tests. Tertiary fertility center. Patients und ergoing IUI. We detected 16 studies that reported on postwash TMC at inseminatio n and IUI outcome. Summary receiver operating characteristics (ROC) curves indic ated a reasonable predictive performance toward IUI outcome, and, at cut-off le vels between 0.8 to 5 million motile spermatozoa, the postwash TMC provided a su bstantial discriminative performance. At these cut-off levels, the specificity of the postwash TMC, defined as the ability to predict failure to become pregnan t, was as high as 100%; the sensitivity of the test, defined as the ability to predict pregnancy, was limited. The postwash TMC at insemination could potential ly be used in counseling patients for either IUI or IVF. However, to enable pati ent counseling before the start of treatment, further studies are needed to esta blish the accuracy of a postwash TMC during the fertility workup rather than at insemination.

关 键 词：人工受精 妊娠结局 精子总数 活动精子 荟萃分析 诊断检测 检验方法 

分 类 号：R714.8[医药卫生—妇产科学]