遗传性血栓形成倾向与妊娠晚期不明原因胎死宫内无关  

Absence of association of inherited thrombophilia with unexplained third-trimester intrauterine fetal death

作　　者：Gonen R. Lavi N. Attias D. 张剑萍 

机构地区：[1]Dept. of Obstetrics and Gynecology, Bnai Zion Medical Center, Haifa, Israel Dr

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第7期8-8,共1页Core Journal in Obstetrics/Gynecology

摘　　要：Objective: The purpose of this study was to investigate the alleged association between thrombophilia and unexplained third- trimester stillbirth. Study design: Case subjects were 37 women with a history of a third- trimester unexplained stillbirth. Control subjects were 46 volunteers, group- matched for ethnic origin, with no history of stillbirth, recurrent fetal loss, or thromboembolism. The pathology report of 34/37 placentas of case subjects was reviewed. Results: The prevalence of at least 1 inherited thrombophilia among case subjects was 37.8% compared with 41.3% among control subjects. (OR = 0.87; 95% CI, 0.32- 2.29). There was no significant difference between the groups with respect to the prevalence of any single inherited thrombophilia. There was, however, a significantly higher prevalence of antiphospholipid antibodies among case subjects compared with control subjects: 47.2% vs 8.7% , respectively (OR = 9.4; 95% CI, 2.5- 42.3). No significant difference was noted in the prevalence of thrombopilia among subjects with or without placental infarcts. Conclusion: We did not find an association between unexplained third- trimester intrauterine fetal death and inherited thrombophilia; however, we did find such an association with antiphospholipid antibodies.Objective: The purpose of this study was to investigate the alleged association between thrombophilia and unexplained third- trimester stillbirth. Study design: Case subjects were 37 women with a history of a third- trimester unexplained stillbirth. Control subjects were 46 volunteers, group- matched for ethnic origin, with no history of stillbirth, recurrent fetal loss, or thromboembolism. The pathology report of 34/37 placentas of case subjects was reviewed. Results: The prevalence of at least 1 inherited thrombophilia among case subjects was 37.8% compared with 41.3% among control subjects. (OR = 0.87; 95% CI, 0.32- 2.29). There was no significant difference between the groups with respect to the prevalence of any single inherited thrombophilia. There was, however, a significantly higher prevalence of antiphospholipid antibodies among case subjects compared with control subjects: 47.2% vs 8.7% , respectively (OR = 9.4; 95% CI, 2.5- 42.3). No significant difference was noted in the prevalence of thrombopilia among subjects with or without placental infarcts. Conclusion: We did not find an association between unexplained third- trimester intrauterine fetal death and inherited thrombophilia; however, we did find such an association with antiphospholipid antibodies.

关 键 词：血栓形成倾向 妊娠晚期 胎死宫内 抗磷脂抗体 胎盘梗死 流产史 无显著性差异 

分 类 号：R714.2[医药卫生—妇产科学]