IL-1受体拮抗物和IL-1β多态性在复发性流产妇女中的表达  

Interleukin- 1 receptor antagonist and in te-rleukin- 1 beta polymorphisms in women with recurrent miscarriage

作　　者：Linjawi S Laird S Blakemore A 宁亮 

机构地区：[1]Biomedical Researc h Centre, Sheffield Hallam University, City Campus, Sheffield, S1 1WB, United Kingdom.Dr

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第10期17-17,共1页Core Journal in Obstetrics/Gynecology

摘　　要：Genotypes and allele distributions for the interleukin (IL)- 1β - 511 C/T and the IL- 1 receptor antagonist gene intron 2 tandem repeat polymorphisms were compared in 206 women with recurrent miscarriage and a control population. No significant differences were observed between the distributions of IL- 1β or IL- 1 receptor antagonist gene alleles in either the recurrent miscarriage group as a whole or when divided according to the cause of recurrent miscarriage compared with controls, which suggests that variation in the IL- 1 receptor antagonist gene and IL- 1β genes individually does not play a role in susceptibility to recurrent miscarriage.Genotypes and allele distributions for the interleukin (IL)- 1β - 511 C/T and the IL- 1 receptor antagonist gene intron 2 tandem repeat polymorphisms were compared in 206 women with recurrent miscarriage and a control population. No significant differences were observed between the distributions of IL- 1β or IL- 1 receptor antagonist gene alleles in either the recurrent miscarriage group as a whole or when divided according to the cause of recurrent miscarriage compared with controls, which suggests that variation in the IL- 1 receptor antagonist gene and IL- 1β genes individually does not play a role in susceptibility to recurrent miscarriage.

关 键 词：IL-1受体 复发性流产 拮抗物 多态性 串联重复 等位基因分布 显著性差异 内含子 

分 类 号：R714.2[医药卫生—妇产科学]