肥胖不影响供卵受孕患者的种植率或妊娠结局  

Obesity does not impact implantation rates or pregnancy outcome in women attempting conception through oocyte donation

作　　者：Styne-Gross A Elkind-Hirsch K Scott Jr. R.T 李跃萍 

机构地区：[1]Repro ductive Medicine Associates of New Jersey, 111 Madison Ave, Morristown, NJ 07962 , United States.Dr

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第10期17-18,共2页Core Journal in Obstetrics/Gynecology

摘　　要：Objective: To independently evaluate the effect of body mass index (BMI) on implantation, pregnancy, and incidence of spontaneous miscarriage using the donor oocyte recipient model. Design: Institutional Review Board- app- roved retrospective data analyses of donor oocyte cycles from 1999 to 2004. Setting: Private assisted reproductive technology (ART) center. Patient(s): Five hundred thirty- six first cycle recipients of donor oocytes. Intervention(s): Data were collected from the first cycle of each donor oocyte recipient included in the study. The body mass index (BMI) of each recipient was calculated using the formula weight (in kilograms)/height (in meters squared). Patients were divided into four groups based on BMI: underweight, normal, overweight, and obese. Pregnancy outcomes in each group were compared. Main Outcome Measure(s): Body mass index, implantation rate, pregnancy rate (PR), miscarriage rate. Result(s): There were no statistically significant differences in the implantation rates, ongoing PRs, or spontaneous abortion rates among patients in the four BMI groups. When further divided into those patients receiving blastocyst vs. day 3 transfers, there was still no effect of BMI on implantation rate, PR, or loss rate among the blastocyst or day 3 donor oocyte recipients. Conclusion(s): Body mass index has no adverse impact on implantation or reproductive outcome in donor oocyte recipients. Therefore, obesity does not appear to exert a negative effect on endometrial receptivity.Objective: To independently evaluate the effect of body mass index (BMI) on implantation, pregnancy, and incidence of spontaneous miscarriage using the donor oocyte recipient model. Design: Institutional Review Board- app- roved retrospective data analyses of donor oocyte cycles from 1999 to 2004. Setting: Private assisted reproductive technology (ART) center. Patient(s): Five hundred thirty- six first cycle recipients of donor oocytes. Intervention(s): Data were collected from the first cycle of each donor oocyte recipient included in the study. The body mass index (BMI) of each recipient was calculated using the formula weight (in kilograms)/height (in meters squared). Patients were divided into four groups based on BMI: underweight, normal, overweight, and obese. Pregnancy outcomes in each group were compared. Main Outcome Measure(s): Body mass index, implantation rate, pregnancy rate (PR), miscarriage rate. Result(s): There were no statistically significant differences in the implantation rates, ongoing PRs, or spontaneous abortion rates among patients in the four BMI groups. When further divided into those patients receiving blastocyst vs. day 3 transfers, there was still no effect of BMI on implantation rate, PR, or loss rate among the blastocyst or day 3 donor oocyte recipients. Conclusion(s): Body mass index has no adverse impact on implantation or reproductive outcome in donor oocyte recipients. Therefore, obesity does not appear to exert a negative effect on endometrial receptivity.

关 键 词：种植率 供卵 妊娠结局 辅助生殖技术 流产率 囊胚移植 胚胎移植 自发流产 正常体重 子宫内膜 

分 类 号：R714.8[医药卫生—妇产科学]