多囊卵巢综合征患者雄激素受体CAG基因长度多态性  

Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome

作　　者：Jskelinen J Korhonen S Voutilainen R 李跃萍 

机构地区：[1]Department of Pediatrics, Kuopio University Hospi tal, PO Box 1777, 70211 Kuopio, Finland.Dr

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第10期22-23,共2页Core Journal in Obstetrics/Gynecology

摘　　要：Objective: To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS). Design: Retrospective case- control study. Setting: University- based clinic. Patient(s): One hundred six nondiabetic women with PCOS and 112 nonhirsute fertile controls. Intervention(s): Androgen receptor gene CAG repeat length was analyzed in women with PCOS and their controls. Main Outcome Measure(s): Androgen receptor gene CAG repeat length in both groups. Result(s): The mean CAGn was 21.5 repeats in both groups (NS; t- test). Furthermore, when the CAGn lengths were divided into three categories (CAGn ≤ 18, 19- 24, ≥ 25), the distribution was similar in both groups (NS; χ 2 test). However, all five women carrying ≤ 15 CAG repeats belonged to the PCOS group. In the PCOS group, CAGn did not correlate with body mass index or serum testosterone concentration. Conclusion(s): Androgen receptor CAGn is not a major determinant of PCOS. However, it may be a significant modulator of androgen- related diseases in some individuals.Objective: To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS). Design: Retrospective case- control study. Setting: University- based clinic. Patient(s): One hundred six nondiabetic women with PCOS and 112 nonhirsute fertile controls. Intervention(s): Androgen receptor gene CAG repeat length was analyzed in women with PCOS and their controls. Main Outcome Measure(s): Androgen receptor gene CAG repeat length in both groups. Result(s): The mean CAGn was 21.5 repeats in both groups (NS; t- test). Furthermore, when the CAGn lengths were divided into three categories (CAGn ≤ 18, 19- 24, ≥ 25), the distribution was similar in both groups (NS; χ 2 test). However, all five women carrying ≤ 15 CAG repeats belonged to the PCOS group. In the PCOS group, CAGn did not correlate with body mass index or serum testosterone concentration. Conclusion(s): Androgen receptor CAGn is not a major determinant of PCOS. However, it may be a significant modulator of androgen- related diseases in some individuals.

关 键 词：多囊卵巢综合征 CAG基因 雄激素受体 基因长度 多态性 教学医院 多毛症 个体发生 患者体重指数 主要决定因素 

分 类 号：R711.75[医药卫生—妇产科学]