补骨脂素联合长波紫外线照射诱导白癜风皮损和非皮损区雀斑样痣的产生  

Psoralen plus ultraviolet A irradiation-induced lentigines arising in vitiligo: Involvement of vitiliginous and normal appearing skin

作　　者：Abdel Naser M.B. Wollina U. El Okby M. El Shiemy S. 牛新武 

机构地区：[1]4 Al Rahman Tower, El Sawah Sq.11281, Cairo, Egypt

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2005年第1期15-15,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Psoralen plus ultraviolet A irradiation (PUVA therapy) is commonly used for the management of vitiligo in which perifollicular repigmentation is the usual response pattern.However, excessive PUVA therapy may be associated with adverse effects.We report a case of generalized vitiligo that has been extensively treated with topical and systemic PUVA therapy for several years with the development of extensive andwidespread stellate and irregularly shaped black and brown macules (lentigines).Interestingly, the lentigines were observed not only in the normally pigmented skin but also within the depigmented lesions that were lacking the perifollicular response pattern.The lesions developed in the exposed and unexposed skin areas.No evidence of skin malignancy was observed clinically and no melanocyte atypia was detected histopathologically.Cryotherapy may be used in the management of the lentigines; however, because of the extent of lesions this was impractical in our case.Psoralen plus ultraviolet A irradiation (PUVA therapy) is commonly used for the management of vitiligo in which perifollicular repigmentation is the usual response pattern.However, excessive PUVA therapy may be associated with adverse effects.We report a case of generalized vitiligo that has been extensively treated with topical and systemic PUVA therapy for several years with the development of extensive andwidespread stellate and irregularly shaped black and brown macules (lentigines).Interestingly, the lentigines were observed not only in the normally pigmented skin but also within the depigmented lesions that were lacking the perifollicular response pattern.The lesions developed in the exposed and unexposed skin areas.No evidence of skin malignancy was observed clinically and no melanocyte atypia was detected histopathologically.Cryotherapy may be used in the management of the lentigines; however, because of the extent of lesions this was impractical in our case.

关 键 词：雀斑样痣 皮损区 白癜 补骨脂素 长波紫外线 泛发性 皮肤恶性肿瘤 冷冻治疗 反应模式 黑色素细胞 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]