万古霉素诱发的线性IgA大疱病表现为中毒性表皮坏死松解症  

Vancomycin-induced linear IgA bullous disease presenting as toxic epidermal necrolysis

作　　者：Waldman M.A. Black D.R. Callen J.P. 王琼 

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2005年第6期22-22,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Linear IgA bullous dermatosis (LABD) is a rare autoimmune vesiculobullous disorder characterized by variable clinical presentations that may mimic bullous pemphigoid, dermatitis herpetiformis, cicatricial pemphigoid and erythema multi- forme. A few cases of drug-induced LABD that clinically resembled toxic epidermal necrolysis (TEN) have been reported. A subset of patients with LABD have been found to be drug-induced: the most common drug being vancomycin. The diagnosisofLABDisconfirmedbythepresenceofalinearband of IgA along the basement membrane zone on direct immunofluorescence microscopy. We report a case of a 77- year-old man who presented to us with vancomycin-induced LABD that presented clinically as TEN, He had a complete recovery over a 3- week period following discontinuation of the vancomycin and the addition of oral dapsone therapy. It is important to be aware that drug-induced LABD can mimic TEN.Linear IgA bullous dermatosis (LABD) is a rare autoimmune vesiculobullous disorder characterized by variable clinical presentations that may mimic bullous pemphigoid, dermatitis herpetiformis, cicatricial pemphigoid and erythema multi- forme. A few cases of drug-induced LABD that clinically resembled toxic epidermal necrolysis (TEN) have been reported. A subset of patients with LABD have been found to be drug-induced: the most common drug being vancomycin. The diagnosisofLABDisconfirmedbythepresenceofalinearband of IgA along the basement membrane zone on direct immunofluorescence microscopy. We report a case of a 77- year-old man who presented to us with vancomycin-induced LABD that presented clinically as TEN, He had a complete recovery over a 3- week period following discontinuation of the vancomycin and the addition of oral dapsone therapy. It is important to be aware that drug-induced LABD can mimic TEN.

关 键 词：IgA大疱病 大疱 多形性红斑 疱疹样皮炎 氨苯砜 直接免疫荧光法 瘢痕性 基膜 于中 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]