环孢霉素A致面部弥漫性皮脂腺增生  

Diffuse sebaceous hyperplasia of the face induced by cyclosporine (Fren)

作　　者：Engel F. Ellero B. Woehl- Jaegle M.- L. Cribier B. 王琼 

机构地区：[1]Clinique Dermatologique des H.opitaux Universitaires de Strasbourg, 1, place de l' H.opital, 67091 Strasbourg Cedex, France

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2005年第8期51-51,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Introduction. Many cutaneous complications have been reported in patients treated with cyclosporine. Alterations of the pilosebaceous follicle are particularly frequent. Hypertrichosis, follicular keratosis, acne and folliculitis are very common. Nevertheless,theoccurrenceofsebaceoushyperplasiaisexceptional. Observation. A 27 year- old man consulted in February 2003 for a papulous eruption of the face. He was treated by cyclosporine and prednisone since his renal transplantation in 1993. The lesions flowed together on the cheeks, forehead and temples. The histological analysis confirmed the diagnosis of sebaceous hyperplasia. There was a perceptible improvement of the cutaneous state after one month of isotretinoin treatment. Discussion. Sebaceous hyperplasia appears in about 10 p. 100 of patients treated with cyclosporine. This side effect occurs only in men of a mean age of 40 years. An increase in sebaceous gland size is often described, but profuse forms are uncommon. Our case report is exceptional because of the young age of the patient, and the occurrence of diffuse sebaceous hyperplasia that appeared a long time after the introduction of cyclosporine.Introduction. Many cutaneous complications have been reported in patients treated with cyclosporine. Alterations of the pilosebaceous follicle are particularly frequent. Hypertrichosis, follicular keratosis, acne and folliculitis are very common. Nevertheless,theoccurrenceofsebaceoushyperplasiaisexceptional. Observation. A 27 year- old man consulted in February 2003 for a papulous eruption of the face. He was treated by cyclosporine and prednisone since his renal transplantation in 1993. The lesions flowed together on the cheeks, forehead and temples. The histological analysis confirmed the diagnosis of sebaceous hyperplasia. There was a perceptible improvement of the cutaneous state after one month of isotretinoin treatment. Discussion. Sebaceous hyperplasia appears in about 10 p. 100 of patients treated with cyclosporine. This side effect occurs only in men of a mean age of 40 years. An increase in sebaceous gland size is often described, but profuse forms are uncommon. Our case report is exceptional because of the young age of the patient, and the occurrence of diffuse sebaceous hyperplasia that appeared a long time after the introduction of cyclosporine.

关 键 词：皮脂腺增生 环孢霉素 弥漫性 毛皮脂腺囊 小乳头 毛囊角化病 皮质腺增生 异维甲酸 组织学检查 皮肤状况 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]