308nm准分子激光治疗白癜风的每周最佳治疗频率  

Optimal weekly frequency of 308-nm excim-er laser treatment in vitiligopatients

作　　者：Hofer A. Hassan A.S. Legat F.J. P. Wolf 张宪旗 

机构地区：[1]Department of Photodermatology, Medical University Graz, Auenbruggerplatz 8, A-8036 Graz,Austria Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2005年第9期2-3,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background:Recently the beneficial effect of excimer laser treatment has been reported for patients with vitiligo. The influence of treatment frequency on this effect is not clear. Objectives:To determine the optimal frequency of 308-nm excimer laser therapy for vitiligo. Methods:In this prospective, university-based hospital study over 12 weeks we enrolled 14 patients. Each had at least three stable vitiligo lesions in the same body area. The three stable vitiligo lesions in each subject were randomly assigned to receive excimer laser treatment once (1×), twice (2×) and three times (3×) weekly, respectively. The initial ultraviolet (UV) dose was 50 mJ cm-2 less than the 308-nm minimal erythematous dose in vitiligo skin. The UV dose was increased at each treatment session according to the erythematous response to the previous treatment. Results:Thirteen subjects were treated for at least 6 weeks; seven were treated for all 12 weeks. At 6 weeks, the repigmentation rates for treated lesions were 8%(1/13) after 1×weekly treatment, 23%(3/13) after 2×weekly treatment and 62%(8/13) after 3×weekly treatment (P=0.0134; 3×vs. 1×weekly); at 12 weeks, these rates were 46%(6/13), 62%(8/13) and 69%(9/13), respectively (P=NS;3×vs. 1 ×weekly). Repigmentation initiation correlated with treatment number, regardless of frequency (P=NS). As shown by Kaplan-Meier analysis, repigmentation occurred earliest in the most frequently treated lesions (P=0.0336). At 12 weeks, the projected repigmentation rates for 1×,2×and 3×weekly treatment approached each other (60%, 79%and 82%, respectively); the mean repigmentation grades (on a scale of 0-5) for 1×,2×and 3×weekly treatment were 1.7, 2.4 and 3.3, respectively(P=0.018;3×.vs. 1×weekly). Laser-induced repigmentation persisted in most cases over the entire follow-up of 12 months after the end of treatment. Conclusions:308-nm excimer laser therapy is effective against vitiligo. Although repigmentation occurs fastest with 3×weekly treatment, the ultimate repigmentation initiBackground:Recently the beneficial effect of excimer laser treatment has been reported for patients with vitiligo. The influence of treatment frequency on this effect is not clear. Objectives:To determine the optimal frequency of 308-nm excimer laser therapy for vitiligo. Methods:In this prospective, university-based hospital study over 12 weeks we enrolled 14 patients. Each had at least three stable vitiligo lesions in the same body area. The three stable vitiligo lesions in each subject were randomly assigned to receive excimer laser treatment once (1×), twice (2×) and three times (3×) weekly, respectively. The initial ultraviolet (UV) dose was 50 mJ cm-2 less than the 308-nm minimal erythematous dose in vitiligo skin. The UV dose was increased at each treatment session according to the erythematous response to the previous treatment. Results:Thirteen subjects were treated for at least 6 weeks; seven were treated for all 12 weeks. At 6 weeks, the repigmentation rates for treated lesions were 8%(1/13) after 1×weekly treatment, 23%(3/13) after 2×weekly treatment and 62%(8/13) after 3×weekly treatment (P=0.0134; 3×vs. 1×weekly); at 12 weeks, these rates were 46%(6/13), 62%(8/13) and 69%(9/13), respectively (P=NS;3×vs. 1 ×weekly). Repigmentation initiation correlated with treatment number, regardless of frequency (P=NS). As shown by Kaplan-Meier analysis, repigmentation occurred earliest in the most frequently treated lesions (P=0.0336). At 12 weeks, the projected repigmentation rates for 1×,2×and 3×weekly treatment approached each other (60%, 79%and 82%, respectively); the mean repigmentation grades (on a scale of 0-5) for 1×,2×and 3×weekly treatment were 1.7, 2.4 and 3.3, respectively(P=0.018;3×.vs. 1×weekly). Laser-induced repigmentation persisted in most cases over the entire follow-up of 12 months after the end of treatment. Conclusions:308-nm excimer laser therapy is effective against vitiligo. Although repigmentation occurs fastest with 3×weekly treatment, the ultimate repigmentation initi

关 键 词：准分子激光 最小红斑量 红斑反应 恢复率 总次数 激光诱导 恢复时间 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]