抗CD20单克隆抗体(美罗华)治疗天疱疮  

Anti- CD20 monoclonal antibody (rituxi- mab) in the treatment of pemphigus

作　　者：Arin M.J. Engert A. Krieg T. Hunzelmann N. 王琼 

机构地区：[1]Department of Dermatology, University of Cologne, 50924 Cologne, Germany

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2005年第12期51-51,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Pemphigus is a severe autoimmune blistering disorder caused by autoantibodies to desmoglein 1 and 3. The disease course is typically severe, thus requiring multiple immunosuppressive agents. The treatment is still challenging and in some patients with recalcitrant disease, therapies fail and therapeutic options are limited. Objectives: To investigate whether depletion of B lymphocytes that are thought to produce disease- causing autoantibodies shows a long- term benefit in pemphigus. Methods: Five patients diagnosed as having pemphigus vulgaris and pemphigus foliaceus were treated with the monoclonal antibody rituximab. Rituximab was administered intravenously at a dosage of 375 mg m- 2 once weekly for 4 weeks. Results: The treatment was well tolerated and all patients showed a good response over a follow- up period of up to 3 years, allowing immunosuppressive treatment to be reduced or terminated. B- cell depletion persisted for 6- 12 months, and in one patient for almost 3 years. Conclusions: This study highlights the prolonged effect and disease control after one single course of rituximab and further extends the spectrum of treatments of bullous autoimmune disorders.Background: Pemphigus is a severe autoimmune blistering disorder caused by autoantibodies to desmoglein 1 and 3. The disease course is typically severe, thus requiring multiple immunosuppressive agents. The treatment is still challenging and in some patients with recalcitrant disease, therapies fail and therapeutic options are limited. Objectives: To investigate whether depletion of B lymphocytes that are thought to produce disease- causing autoantibodies shows a long- term benefit in pemphigus. Methods: Five patients diagnosed as having pemphigus vulgaris and pemphigus foliaceus were treated with the monoclonal antibody rituximab. Rituximab was administered intravenously at a dosage of 375 mg m- 2 once weekly for 4 weeks. Results: The treatment was well tolerated and all patients showed a good response over a follow- up period of up to 3 years, allowing immunosuppressive treatment to be reduced or terminated. B- cell depletion persisted for 6- 12 months, and in one patient for almost 3 years. Conclusions: This study highlights the prolonged effect and disease control after one single course of rituximab and further extends the spectrum of treatments of bullous autoimmune disorders.

关 键 词：CD20 美罗华 单克隆抗体 桥粒芯蛋白 大疱 自身抗体 自身免疫疾病 免疫抑制剂 致病性 控制能力 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]