巨细胞病毒通过母乳传播给极低出生体重儿  

Cytomegalovirus transmission to extremely low-birth weight infants through breast milk

作　　者：Doctor S. Friedman S. Dunn M. S. 李开 

机构地区：[1]Dept. Newborn and Devmtl. Paediatr. , Sunnybrook Women’s Coll. Hlth. S. , Women’s College Campus, 76 Grenville Street, Toronto, Ont. M5S 1B2, Canada

出　　处：《世界核心医学期刊文摘（儿科学分册）》2005年第6期7-8,共2页

摘　　要：Aim: To determine the incidence, timing and clinical significance of acquired postnatal cytomegalovirus (CMV)-in extremely low-birthweight (ELBW) infants. Methods: Prospective, longitudinal surveillance study. ELBW infants were recruited in the first week of life. Maternal blood was tested for CMV-specific IgG antibodies. Weekly urine samples were obtained from infants for CMV culture and rapid antigen testing. Data were collected regarding clinical course and breast milk intake. Results: Of 181 eligible infants, 119 infants, born to 101 mothers, were enrolled. Eighty of the 101 mothers had their serum checked for CMV status. Seventy percent of those tested were seropositive for CMV. Of the 65 infants born to seropositive mothers, 94%received breast milk during their hospital stay. Complete urine collection was obtained in 92 infants. CMV was cultured from the urine of only four infants, all of whom were born to seropositive mothers. Only one of these four infants was symptomatic. The range at which CMV was first detected was between 48 and 72 postnatal days of age. Conclusions: Despite a very high CMV seropositivity rate in mothers of ELBW infants, and the previously reported high rate of CMV excretion into breast milk, the incidence of postnatal CMV transmission was extremely low in our study.Aim: To determine the incidence, timing and clinical significance of acquired postnatal cytomegalovirus (CMV)-in extremely low-birthweight (ELBW) infants. Methods: Prospective, longitudinal surveillance study. ELBW infants were recruited in the first week of life. Maternal blood was tested for CMV-specific IgG antibodies. Weekly urine samples were obtained from infants for CMV culture and rapid antigen testing. Data were collected regarding clinical course and breast milk intake. Results: Of 181 eligible infants, 119 infants, born to 101 mothers, were enrolled. Eighty of the 101 mothers had their serum checked for CMV status. Seventy percent of those tested were seropositive for CMV. Of the 65 infants born to seropositive mothers, 94%received breast milk during their hospital stay. Complete urine collection was obtained in 92 infants. CMV was cultured from the urine of only four infants, all of whom were born to seropositive mothers. Only one of these four infants was symptomatic. The range at which CMV was first detected was between 48 and 72 postnatal days of age. Conclusions: Despite a very high CMV seropositivity rate in mothers of ELBW infants, and the previously reported high rate of CMV excretion into breast milk, the incidence of postnatal CMV transmission was extremely low in our study.

关 键 词：极低出生体重儿 巨细胞病毒 病毒培养 感染征象 出生后 母乳喂养 后天获得性 临床病程 抗体检测 抗原检测 

分 类 号：R722.1[医药卫生—儿科]