生长激素补充疗法对短肠综合征患儿单独肠道内营养时间延迟的作用  

The effect of growth hormone supplementation on late nutritional independence in pediatric patients with short bowel syndrome

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作  者:Ladd A.P. Grosfeld J.L. Pescovitz O.H. Johnson N.B. 宁亮 

机构地区:[1]Department of Surgery, Indiana Univ.School of Medicine, Riley Children's Hospital, Indianapolis, IN 46202, United States

出  处:《世界核心医学期刊文摘(儿科学分册)》2005年第7期43-44,共2页

摘  要:Purpose: The use of growth hormone (GH) supplementation for intestinal adaptation among adult patients with short bowel syndrome (SBS) has provided mixed results.This report examines the effect of GH supplementation on SBS in pediatric patients.Methods: Two girls with SBS from neonatal gastrointestinal catastrophes received exogenous GH at 0.3 mg/kg per week subcutaneously and concurrent glutamine supplementation, beginning at 6 and 61/2 years of age.Changes in growth (height and weight) and changes in enteral and parenteral energy requirements were evaluated.Results: Treatment duration was 8 and 2.5 years, respectively.Patient weights increased from the 5th to the 41st percentile and from the 17th to the 23rd percentile, respectively.Height increased from the 1st to the 57th percentile in the former patient and increased from less than the 1st to the 17th percentile in the latter.Both patients are independent of parenteral nutrition and take enteral nutrition alone.Tolerance for enteral diets was significantly improved in each girl, with only 2 stools per day maintained in one patient.Conclusions: The data show that late exogenous treatment with GH and glutamine supplementation improved growth parameters in pediatric patients with SBS.Growth hormone and glutamine supplementation may be beneficial in promoting late intestinal adaptation in pediatric patients with SBS.These data also suggest that these adjuncts may be useful in the early phases of intestinal adaptation.Purpose: The use of growth hormone (GH) supplementation for intestinal adaptation among adult patients with short bowel syndrome (SBS) has provided mixed results.This report examines the effect of GH supplementation on SBS in pediatric patients.Methods: Two girls with SBS from neonatal gastrointestinal catastrophes received exogenous GH at 0.3 mg/kg per week subcutaneously and concurrent glutamine supplementation, beginning at 6 and 61/2 years of age.Changes in growth (height and weight) and changes in enteral and parenteral energy requirements were evaluated.Results: Treatment duration was 8 and 2.5 years, respectively.Patient weights increased from the 5th to the 41st percentile and from the 17th to the 23rd percentile, respectively.Height increased from the 1st to the 57th percentile in the former patient and increased from less than the 1st to the 17th percentile in the latter.Both patients are independent of parenteral nutrition and take enteral nutrition alone.Tolerance for enteral diets was significantly improved in each girl, with only 2 stools per day maintained in one patient.Conclusions: The data show that late exogenous treatment with GH and glutamine supplementation improved growth parameters in pediatric patients with SBS.Growth hormone and glutamine supplementation may be beneficial in promoting late intestinal adaptation in pediatric patients with SBS.These data also suggest that these adjuncts may be useful in the early phases of intestinal adaptation.

关 键 词:短肠综合征 激素补充疗法 时间延迟 出生后 生长参数 

分 类 号:R726.5[医药卫生—儿科]

 

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