多中心调查:患腹部疾病的1型糖尿病儿童的身体测量指标、代谢控制和甲状腺自身免疫状况  

Anthropometry, metabolic control, and thyroid autoimmunity in type 1 diabetes with celiac disease: A multicenter survey

作　　者：Kaspers S. Kordonouri O. Schober E. 李开 

出　　处：《世界核心医学期刊文摘（儿科学分册）》2005年第9期23-23,共1页

摘　　要：To investigate the influence of celiac disease (CD) on growth and metabolic control in a nationwide cohort of children and adolescents with type 1 diabetes (T1D). We analyzed data from 19, 796 pediatric patients with T1D in the German pediatric multicenter DPV-database for occurrence of CD. CD-specific antibodies were present in 1326 patients (6. 7% ). The diagnosis was confirmed in 127 patients (0. 6% ) by small-bowel biopsy. Female subjects were significantly more predisposed to have T1D and CD. The CD-affected patients in our cohort were significantly younger at diabetes onset. Furthermore, they had significantly lower height-SDS at onset (-0. 49 vs-0. 06, P < .05), a difference that increased during the course of the disease (-0. 80 vs-0. 26 after 9 years of diabetes, P < . 05). In addition, body mass index-SDS significantly differed between the groups (0. 22 vs 0. 47, P < . 05). Evidence for thyroid disease was more commonly observed in the T1D with CD group (6. 3% vs 2. 3% , P < . 05). HbA1c values were lower in the patients with T1D and CD. The CD-positive patients were characterized by earlier onset of diabetes and decreased growth and weight gain. These findings emphasize the clinical relevance of celiac disease in patients with autoimmune diabetes.To investigate the influence of celiac disease (CD) on growth and metabolic control in a nationwide cohort of children and adolescents with type 1 diabetes (T1D). We analyzed data from 19, 796 pediatric patients with T1D in the German pediatric multicenter DPV-database for occurrence of CD. CD-specific antibodies were present in 1326 patients (6. 7% ). The diagnosis was confirmed in 127 patients (0. 6% ) by small-bowel biopsy. Female subjects were significantly more predisposed to have T1D and CD. The CD-affected patients in our cohort were significantly younger at diabetes onset. Furthermore, they had significantly lower height-SDS at onset (-0. 49 vs-0. 06, P < .05), a difference that increased during the course of the disease (-0. 80 vs-0. 26 after 9 years of diabetes, P < . 05). In addition, body mass index-SDS significantly differed between the groups (0. 22 vs 0. 47, P < . 05). Evidence for thyroid disease was more commonly observed in the T1D with CD group (6. 3% vs 2. 3% , P < . 05). HbA1c values were lower in the patients with T1D and CD. The CD-positive patients were characterized by earlier onset of diabetes and decreased growth and weight gain. These findings emphasize the clinical relevance of celiac disease in patients with autoimmune diabetes.

关 键 词：腹部疾病 代谢控制 自身免疫 肠组织活检 临床相关性 数据资料 生长发育 疾病发作 特异性 

分 类 号：R725.8[医药卫生—儿科]