儿科临床中一项实用的检测方法:粪胰肽酶E-1的测定  

Fecal elastase- 1: A useful test in pediatric practice (Fren)

作　　者：David-Henriau L. Bui S. Molinari I. T. Lamireau 朱新菊 

机构地区：[1]Unité de Gastroenté rologie Pé diatrique, Dé partement de Pé diatrie, CHU de Bordeaux, place Amé lie- Raba- Lé on, 33076,BordeauxCedex, France

出　　处：《世界核心医学期刊文摘（儿科学分册）》2005年第12期15-15,共1页

摘　　要：- To study fecal elastase- 1 (E1F) and chymotrypsin (ChT) in stools for the diagnosis of pancreatic insufficiency in pediatric practice. - Materials and methods. - E1F and ChT were measured in stools of 198 children divided in 3 groups: 49 children without any digestive disease (group A), 71 children with pancreatic diseases (group B), and 78 children with nonpancreatic digestive diseases (group C). Results. - In group B, E1F values were very low in 64 children and normal in 7 children without pancreatic insufficiency (6 children with cystic fibrosis and 1 with chronic pancreatitis). ChT values were normal in children without pancreatic insufficiency but also in half of children treated with pancreatic enzymes. Decreased E1F values were seen in 2 children (4% ) in the group A and 22 children (28% ) in the group C, especially those with acute gastroenteritis or celiac disease. Conclusion. - E1F is a simple, non-invasive, useful tool for the diagnosis of pancreatic insuffi ciency in children with growth failure or chronic diarrhea, and those with cystic fibrosis. Nevertheless, low values may be found in diseases with villous atrophy or very liquid stools.- To study fecal elastase- 1 (E1F) and chymotrypsin (ChT) in stools for the diagnosis of pancreatic insufficiency in pediatric practice. - Materials and methods. - E1F and ChT were measured in stools of 198 children divided in 3 groups: 49 children without any digestive disease (group A), 71 children with pancreatic diseases (group B), and 78 children with nonpancreatic digestive diseases (group C). Results. - In group B, E1F values were very low in 64 children and normal in 7 children without pancreatic insufficiency (6 children with cystic fibrosis and 1 with chronic pancreatitis). ChT values were normal in children without pancreatic insufficiency but also in half of children treated with pancreatic enzymes. Decreased E1F values were seen in 2 children (4% ) in the group A and 22 children (28% ) in the group C, especially those with acute gastroenteritis or celiac disease. Conclusion. - E1F is a simple, non-invasive, useful tool for the diagnosis of pancreatic insuffi ciency in children with growth failure or chronic diarrhea, and those with cystic fibrosis. Nevertheless, low values may be found in diseases with villous atrophy or very liquid stools.

关 键 词：肽酶 消化性疾病 慢性胰腺炎 胰腺疾病 胰腺功能 急性肠胃炎 生长发育障碍 疾病患儿 糜蛋白酶 水样便 

分 类 号：R446.13[医药卫生—诊断学]