利用在体冠状动脉内超声射频数据分析评价的非罪犯病变冠状动脉斑块的构成与临床表现相关  

Coronary plaque composition of nonculprit lesions, assessed by in vivo intracoronary ultrasound radio frequency data analysis, is related to clinical presentation

作　　者：Rodriguez-Granillo G.A. Mc Fadden E.P. Valgimigli M. P.W. Serruys 韩瑞娟 

机构地区：[1]Erasmus Medical Center, Thoraxcenter, Rotterdam, Netherlands Dr.

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2006年第7期10-11,共2页

摘　　要：Background: Identification of subclinical high-risk plaques is potentially important because they may have greater likelihood of rupture and subsequent thrombosis. The purpose of this study was to assess the relationship between plaque composition determined by intravascular ultrasound(IVUS) radio frequency(RF) data analysis and clinical presentation. Methods: In 55 patients, a nonculprit vessel with< 50%diameter stenosis was studied with IVUS. Tissue maps were reconstructed from RF data using IVUS-Virtual Histology software. Results: Mean percentage of the different plaque components were 0.99%±0.9%, calcium; 68.04%±9.8%, fibrous; 19.31%±7.3%, fibrolipidic; and 9.43%±6.6%, lipid core. Mean lipid core percentage was significantly larger in patients with acute coronary syndrome(ACS) when compared with stable patients(12.26%±7.0%vs 7.40%±5.5%, P=.006). In addition, stable patients showed more fibrotic vessels(70.97%±9.3%vs 63.96%±9.1%, P=.007). There was no significant difference for either mean calcium(1.20%±1.1%vs 0.83%±0.7%, P=.124) or fibrolipidic(20.57%±6.9%vs 18.40%±7.6%, P=.281) percentages in ACS and stable patients, respectively. Vessel area obstruction did not differ between groups(46.49%±10.9%vs 42.83%±11.8%, P=.221). There was a significant, albeit weak, positive correlation between lipid core percentage and stenosis severity as determined by vessel area obstruction(r=0.34, P=.015). Conclusions: In this study, plaque characterization of nonculprit vessels using spectral analysis of IVUS RF data analysis was significantly related to clinical presentation. Percentage of lipid core, a feature related to acute coronary events and worse prognosis, was significantly larger in patients with ACS. Conversely, stable patients showed more fibrotic content.Background: Identification of subclinical high-risk plaques is potentially important because they may have greater likelihood of rupture and subsequent thrombosis. The purpose of this study was to assess the relationship between plaque composition determined by intravascular ultrasound(IVUS) radio frequency(RF) data analysis and clinical presentation. Methods: In 55 patients, a nonculprit vessel with< 50%diameter stenosis was studied with IVUS. Tissue maps were reconstructed from RF data using IVUS-Virtual Histology software. Results: Mean percentage of the different plaque components were 0.99%±0.9%, calcium; 68.04%±9.8%, fibrous; 19.31%±7.3%, fibrolipidic; and 9.43%±6.6%, lipid core. Mean lipid core percentage was significantly larger in patients with acute coronary syndrome(ACS) when compared with stable patients(12.26%±7.0%vs 7.40%±5.5%, P=.006). In addition, stable patients showed more fibrotic vessels(70.97%±9.3%vs 63.96%±9.1%, P=.007). There was no significant difference for either mean calcium(1.20%±1.1%vs 0.83%±0.7%, P=.124) or fibrolipidic(20.57%±6.9%vs 18.40%±7.6%, P=.281) percentages in ACS and stable patients, respectively. Vessel area obstruction did not differ between groups(46.49%±10.9%vs 42.83%±11.8%, P=.221). There was a significant, albeit weak, positive correlation between lipid core percentage and stenosis severity as determined by vessel area obstruction(r=0.34, P=.015). Conclusions: In this study, plaque characterization of nonculprit vessels using spectral analysis of IVUS RF data analysis was significantly related to clinical presentation. Percentage of lipid core, a feature related to acute coronary events and worse prognosis, was significantly larger in patients with ACS. Conversely, stable patients showed more fibrotic content.

关 键 词：冠状动脉斑块 冠状动脉内超声 罪犯血管 血管内超声 血管阻塞 数据分析 血栓形成 数据重建 虚拟组织 

分 类 号：R543[医药卫生—心血管疾病]