不论左室容量有无差异女性左室射血分数较男性高:达拉斯心脏研究  

Women have higher left ventricular ejection fractions than men independent of differences in left ventricular volume: The Dallas heart study

作　　者：Chung A.K. Das S.R. Leonard D. M.H. Drazner 朱冰坡 

机构地区：[1]University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9047, United States Dr.

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2006年第7期34-35,共2页

摘　　要：Background -Although gender-specific criteria are common for defining cardiac traits such as left ventricular hypertrophy, left ventricular ejection fraction(LVEF) thresholds widely used in clinical practice have traditionally been the same for women and men, perhaps because it remains uncertain whether there is a systematic difference in LVEF between genders. Methods and Results -Using cardiac magnetic resonance imaging in a probability-based sample of Dallas County residents aged 30 to 65 years(1435 women and 1183 men), we compared LVEF in women and men. The association of gender with stroke volume independent of end-diastolic volume(EDV) or other potential confounders was assessed by multivariable analysis. Gender-specific thresholds for a low LVEF were defined at the 2.5th percentile in women and men from a healthy reference subpopulation. The median(25th, 75th percentile) LVEF was higher in women than in men(75%[70%, 79%] in women versus 70%[65%, 75%] in men, P< 0.001). Left ventricular EDV and end-systolic volume indexed to body surface area were smaller in women than in men(P< 0.001 for both). Gender remained significantly associated with stroke volume, independent of EDV and other potential confounders in multivariable analysis. A low LVEF was defined as below 61%in women and below 55%in men. Conclusions -Women have a higher LVEF than men in the general population, secondary to a higher stroke volume for a given EDV independent of known potential confounders.Background -Although gender-specific criteria are common for defining cardiac traits such as left ventricular hypertrophy, left ventricular ejection fraction(LVEF) thresholds widely used in clinical practice have traditionally been the same for women and men, perhaps because it remains uncertain whether there is a systematic difference in LVEF between genders. Methods and Results -Using cardiac magnetic resonance imaging in a probability-based sample of Dallas County residents aged 30 to 65 years(1435 women and 1183 men), we compared LVEF in women and men. The association of gender with stroke volume independent of end-diastolic volume(EDV) or other potential confounders was assessed by multivariable analysis. Gender-specific thresholds for a low LVEF were defined at the 2.5th percentile in women and men from a healthy reference subpopulation. The median(25th, 75th percentile) LVEF was higher in women than in men(75%[70%, 79%] in women versus 70%[65%, 75%] in men, P< 0.001). Left ventricular EDV and end-systolic volume indexed to body surface area were smaller in women than in men(P< 0.001 for both). Gender remained significantly associated with stroke volume, independent of EDV and other potential confounders in multivariable analysis. A low LVEF was defined as below 61%in women and below 55%in men. Conclusions -Women have a higher LVEF than men in the general population, secondary to a higher stroke volume for a given EDV independent of known potential confounders.

关 键 词：射血分数 达拉斯 舒张期末容积 每搏输出量 收缩期末容积 心室肥厚 常住居民 混杂因素 临床实践 体 

分 类 号：R541[医药卫生—心血管疾病]