心力衰竭史预测抗心律失常治疗疗效:AVID(抗心律失常药物与埋藏式除颤器治疗比较)研究的资料  

A history of heart failure predicts arrhythmia treatment efficacy: Data from the Antiarrythmics versus Implantable Defibrillators (AVID) Study

作　　者：Brodsky M.A. McAnulty J. Zipes D.P. 吴晓燕 

机构地区：[1]Dr.Kaiser Permanente, Honolulu, HI, United States

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2007年第3期15-15,共1页

摘　　要：背景:在危及生命的室性心动过速(VT)存活者中,VT发作前的慢性心力衰竭病史(HxCHF)能相对于已测得的左心室射血分数(LVEF)提供不同的预后信息。方法:作者评估了AVID研究中患者的预后。Background: In survivors of life-threatening ventricular tachycardia(VT), a history of CHF(HxCHF) before the VT episode may provide different prognostic information than their measured left ventricular ejection fraction(LVEF). Methods: We evaluated outcomes from patients in the AVID study. Patients were included in the study if they presented with ventricular fibrillation, VT with syncope or VT with hemodynamic compromise, and LVEF ≤40%. Treatment options included implantable cardioverter defibrillator(ICD) or antiarrhythmic drugs(AAD), usually amiodarone. Results: As expected, a HxCHF is associated with an increased and high risk of arrhythmic and nonarrhythmic death. However, an interaction was observed between arrhythmia treatment(ICD or AAD)and HxCHF status: the survival advantage with an ICD, as compared with AAD therapy, is largely restricted to HxCHF patients. Conclusions: The ICD is no better than AAD therapy in preventing arrhythmic death in patients with no HxCHF. In this data set, a HxCHF is somewhat more accurate in predicting prognosis and the response to therapy than a reduced LVEF.

关 键 词：埋藏式除颤器 抗心律失常药物 AVID 左心室射血分数 预后信息 心室纤颤 存活者 血流动力学 数据 

分 类 号：R541.6[医药卫生—心血管疾病] R541.7[医药卫生—内科学]