人参四逆汤成分的研究  

Research of Active Components in Renshensili Recipe

作　　者：徐暾海[1] 宋风瑞[2] 赵洪峰[1] 王勇[2] 司云珊[1] 刘志强[2] 徐雅娟[1] 

机构地区：[1]吉林省中医中药研究院,长春130021 [2]中国科学院长春应用化学研究所,长春130021

出　　处：《中国医药学报》2002年第7期406-408,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金

摘　　要：利用ESI/MS^n、LC/MS、MALDI-TOF/MS等技术,从人参四逆汤水煎液中分析和鉴定了10种二萜生物碱:苯甲酰中乌头碱benzoylmesaconitine、苯甲酰乌头碱henzoylaconitine、苯甲酰次乌头碱benzoylhypacoitine、尼奥灵neoline、附子灵fuziline、14-乙酰基塔拉地萨敏14-acetyl-talatisamine、苯甲酰次乌头碱亚油酸酯14-benzoylhypaconine-8-linoleate、苯甲酰去氧乌头碱亚油酸酯14-benzoydeoxyaconine-8-oleate、苯甲酰次乌头碱棕榈酸酯14-benzoylhypaconine-8-palmitate、塔拉地萨敏talatisamine和人参皂甙R_(a1)、R_(a2)、R_(b1)、R_(b2)、R_(b3)、R_c、R_d、R_e、R_(g1)、R_(g2)、R_(g3)、R_f等12种人参皂甙。脂肪酸酯型生物碱和苯甲酰类生物碱的提取组分有抗失血性休克作用和弱的正性肌力作用。人参皂甙的提取组分具有明显的负性肌力作用。ESI/MSn、LC/MC and MALDI - TOF/MS technique were used to analyze and authenticate 10 kinds of diterpene alkaloid from the water- decocted liquid of renshensili recipe: benzoylmesaconitine、benzoylaconitine、benzoyl-hypaconitine、neoline、fuzilne、14 - acetyl-talatisarnin、14 - benzyolhypaconitine - 8-linoleate、14 - benzyoldeoxya-conitine - 8 - linoleate、14 - benzyolhypaconitine - 8-palmitate、talatisamine and 12 kinds of Tanax ginseng B. A. Mey Ra1、Ra2、Rb1、Rb2、Rb3、Rc、Rd、Re、Rg1、Rg2、Rg3 and Rf. Lipacidester alkaloid and extracted component of benzoy-lalkaloid have anti - shock of blood loss and weak positive muscle power action. The extracted component of Tanax ginseng B. A. Mey has marked negative muscle power action.

关 键 词：人参四逆汤 成分 二萜生物碱 人参皂甙 软电离质谱 

分 类 号：R289.5[医药卫生—方剂学]