血清sVCAM-1水平与2型糖尿病脑梗死关系探讨  

Study on changes of Soluble Vascular Cell Adhesion Molecule-1 in Type 2 Diabetes Mellitus

作　　者：韩华[1] 耿芹[1] 

机构地区：[1]山东省淄博市中心医院内分泌科

出　　处：《临床医药实践》2009年第7Z期1827-1828,共2页Proceeding of Clinical Medicine

摘　　要：目的:探讨血清中可溶性血管细胞黏附分子-1(sVCAM-1)水平与2型糖尿病(T2DM)患者并发脑梗死的关系探讨。方法:应用ELISA法检测了68例T2DM患者血浆sVCAM-1水平,并且与20例健康人作对照。结果:T2DM各组血清sVCAM-1水平明显高于健康对照组(P【0.01);无脑梗死组、小灶性脑梗死组、大面积脑梗死组含量逐步升高(P【0.01);血清sVCAM-1水平与LDL-C、TG、TC呈正相关(P【0.05)。结论:血清sVCAM-1参与2型糖尿病脑血管并发症的发生与发展,可作为早期2型糖尿病脑血管并发症发生的预测及检测指标。Objective:To investgate the relationship between soluble vascular cell adhesion molecule-1(sVCAM-1) in type 2 diabetes mellitus(T2DM). Methods:Plasma levels of sVCAM-1were measured by ELISA in 68 T2DM patients and 20 healthy controls. Results The plasma levels of sVCAM-1 in T2DM patients were much higher than those in healthy controls (P<0.01).The plasma levels of sVCAM-1 in T2DM patients with cerebral infarction were higher than those in T2DM patients without vascule complication (P<0.01). sVCAM-1 had positive correlation with LDL-C、TG、TC(P<0.05).Conclusions :Serum sVCAM-1 might participate in the course of diabetic microangiopathy

关 键 词：2型糖尿病 可溶性血管细胞黏附分子-1 血管病变 

分 类 号：R587.1[医药卫生—内分泌] R743.3[医药卫生—内科学]