通脉降脂片对老年冠心病的疗效观察及机制探讨  

Effective Observation and Mechanism of TMJZT on Senile Coronary Heart Disease

作　　者：张利凡 余胜利 赵红卫 

机构地区：[1]湖北黄石四医院内科

出　　处：《临床医药实践》2009年第7Z期1890-1892,共3页Proceeding of Clinical Medicine

摘　　要：目的:观察通脉降脂片治疗老年冠心病心绞痛的临床疗效,初步探索其作用机制。方法:将80例老年冠心病心绞痛患者随机分为通脉降脂片组(40例,常规西药加通脉降脂片)与单纯西药治疗组(40例,单用西药治疗),观察治疗前后血浆内皮素(ET)与降钙素基因相关肽(CGRP)含量,临床症状和心电图的变化,并选择30例门诊健康体检者为正常组进行对比。结果:治疗前与治疗后两组患者ET明显高于健康人(P【0.01),CGRP明显低于健康人(P【0.01),通脉降脂片组临床疗效总有效率及心电图疗效总有效率明显优于西药对照组(P【0.01);两组患者ET均明显降低,CGRP明显升高,但是通脉降脂组优于西药对照组(P【0.01)。结论:通脉降脂片可抑制血浆ET过量释放,同时提高血浆CGRP浓度,具有良好的抗心肌缺血作用,对老年冠心病心绞痛有较好的疗效。Objective: To observe the curative effect of TMJZT on senile coronary heart disease(CHD) and its mecha-nism. Methods: Eighty patients were divided into two groups randomly. Group Ⅰ(n=40) was treated by TMJZT adding up general medicine;Group Ⅱ(n=40)only by common medicine. The changes of the ET and CGRP contents before and after treatment were observed,and the symtpoms and ECG were compered with healthy people(n=30). Results: The ET contents of group ⅠandⅡwere both higher than healthy people before and after treatment (P<0.01).CGRP was significantly lower than the healthy people, but the group Ⅰwas higher than to the group Ⅱ in general effection and ECG change. Conclusion: TMJZT can inhibit the release of serum ET and increase the serum CGRP. There is good effect on ischemis myocardiopathy in CHD.

关 键 词：通脉降脂片 老年冠心病 心绞痛 

分 类 号：R259[医药卫生—中西医结合]