支气管扩张稳定期与急性加重期气道炎症关系的研究  

A Study On the Airway Inflammation In Stable and Acute Exacerbating Bronchiectasis.

作　　者：李敏菁[1] 胡少芝[1] 罗志扬[1] 温业良[1] 

机构地区：[1]广东省佛山市第一人民医院呼吸内科

出　　处：《临床医药实践》2009年第8Z期1909-1912,共4页Proceeding of Clinical Medicine

摘　　要：目的:了解稳定期及急性加重期支气管扩张患者气道内炎症的情况。方法:对我院2006年3月～2008年3月确诊支气管扩张的患者(支扩组)48例以及我院健康医务工作者(对照组)10例分别采取放射免疫分析的方法测定痰以及血浆中的白细胞介素以及肿瘤坏死因子的含量以及对其水平作比较分析。结果:支气管扩张患者稳定期及急性加重期气道IL-6、IL-8、TNF-α以及中性粒细胞水平均较对照组高,且在急性加重期增高得更为明显。急性加重期支气管扩张患者气道中的中性粒细胞水平与IL-8和TNF-α水平有相关性;稳定期支气管扩张患者气道中的中性粒细胞水平只与IL-8水平有相关性。结论:支气管扩张患者的气道内存在以中性粒细胞为特征的慢性气道炎症,且在急性加重期表现得更为明显。Objective:To investigate the bronchiectasis airway inflammation during the stable and acute exacerbation period.Methods:Patients who being diagnosed as bronchiectasis during the period between March 2006 and March 2008 in my hospital were total 48 subjects.Used radiommunoassay analysis to test Interleukin and tumor necrosis factor in the sputum and blood. Results:Airway IL-6、IL-8、TNF-αand neutrophil levels for patients with bronchiectasis were higher than the contrast group during the stable and acute exacerbation periods.Moreover,theyincreased more obviously during the acute exacerbation period. The neutrophil level was correlative obviously to IL-8 level for patients with bronchiectasis during the acute exacerbation period; it also was correlative to TNF-α level.The neutrophil level was only correlative to IL-8 level for patients with bronchiectasis during the stable period. Conclusion:There is chronic airway inflammation with a characteristic of neutrophil on the patients with bronchiectasis.

关 键 词：支气管扩张 白细胞介素-6 白细胞介素-8 肿瘤坏死因子 

分 类 号：R562.22[医药卫生—呼吸系统]