干扰素α-2α联合中药治疗HbeAg阳性慢性乙型肝炎的临床观察  

作　　者：向晓玲 蔡杰 杨云 

机构地区：[1]四川省第八人民医院,621000

出　　处：《临床医药实践》2009年第12X期904-905,共2页Proceeding of Clinical Medicine

摘　　要：目的:观察干扰素α-2α联合中药治疗HbeAg阳性慢性乙型肝炎的临床疗效。方法:62例HbeAg阳性慢性乙型肝炎患者随机分为两组,治疗组接受干扰素α-2α联合中药治疗,对照组单纯接受中药治疗。结果:治疗组与对照组HBV、DNA阴转率分别为82.6%和46.7%,差异具有统计学意义,同时治疗组HbeAg阴转率和ALT复常率均高于对照组(46.9%,16.7%,P<0.01;78.1%,50.0%,P<0.05)。两组不良反应发生率相近。结论:干扰素α-2α联合中药治疗HbeAg阳性慢性乙型肝炎可有效地提高HbeAg阴转率和ALT复常率,并且可以缩短干扰素α-2α治疗疗程。Objective:Observation of interferon α-2α positive HbeAg combined with TCM treatment of chronic hepatitis type B(CHB) treatment.Methods:HbeAg positive 62 patients with CHB were randomly divided into 2 groups,treatment group received interferon α-2α combined with TCM treatment,the control group simply accept the TCM treatment.Results:Treatment group and control group HBVDNA conversion rates were 82.6% and 46.7%,with a significant difference,At the same time,the treatment group HbeAg conversion rate and ALT normalization rate were higher (46.9% vs 16.7%,P<0.01 and 78.1% of 50.0%,P<0.05).The two groups is similar to the incidence of adverse reactions.Conclusion:Interferon α-2α positive HbeAg combined with TCM treatment of CHB can effectively improve conversion rates HbeAg and ALT normalization rates,And can Shorten the treatment course of interferon α-2α.

关 键 词：干扰素 中药疗法 慢性乙型肝炎 

分 类 号：R512.62[医药卫生—内科学]