急诊PCI治疗AMI患者神经内分泌变化的临床研究  

Study of Neuroendocrine change in patients with ST Segment elevation Acute Myocardial Infarction using PCI

作　　者：杨延民[1] 崔维刚[1] 邹建峰[1] 吴茂源[1] 宋霞[1] 

机构地区：[1]日照市人民医院心血管内科,山东日照276821

出　　处：《临床医药实践》2010年第8X期1032-1033,共2页Proceeding of Clinical Medicine

摘　　要：目的:探讨急诊PCI治疗急性ST抬高型心肌梗死(STEMI)神经内分泌变化及其临床价值。方法:将行急诊PCI的80例急性STEMI患者分为二组;直接PCI组45例,溶栓组35例,测定外周血中ET等神经内分泌因子浓度水平。分别描记神经内分泌的浓度与时间曲线。比较心电图ST段和左室射血分数(LVEF),评价心功能。结果:治疗后神经内分泌因子均迅速下降,治疗后两组间CTNI的水平没有差别(P>0.05),但PCI组的CTNI下降较TT组快,酶峰PCI组较TT组提前。神经内分泌与CTNI变化呈正相关(P<0.01)。术后3个月PCI组LVEF明显高于溶栓组(P<0.05)。结论:直接PCI治疗急性STEMI较溶栓组能够明显改善恶化的神经内分泌变化,使CTNI的酶峰提前、减轻对心肌的损害,心肌血流灌注改善。Objective:To study neuroendocrine and clinical value of using PCI for STEMI.Methods:80 patients with STEMI were divided into two groups,Thrombolytic therapy group(TT 35 cases),PCI group(PCI 45 cases).The plasma ET etc.neuroendocrine factors levels in patients were measured.The ST segment were measured after PCI and TT.LVEF was measured,In order to evaluate heart function.Results:The neuroendocrine factors declined rapidly after therapy.The CTNI have no difference between the two groups before and after therapy(P>0.05),but PCI group declined rapidly,The peak of PCI group is ahead of TT group.There was a positive correlation between neuroendocrine and Troponin I.After 3 months PCI groups was significantly high than TT groups(P<0.05).Conclusion:Deteriorated neuroendocrine change were significantly improved with PCI,which brought forward the peak of CTNI、relieved damage for myocardium、improved perfusion.

关 键 词：急性心肌梗死 神经内分泌 经皮冠状动脉介入治疗 血栓溶解 

分 类 号：R542.22[医药卫生—心血管疾病]